湖北医药学院学报2017，Vol.36Issue(4)：315-324,10.DOI:10.13819/j.issn.1006-9674.2017.04.008
比较定容通气与压力限定通气在早产儿中效益评估的Meta分析
Meta-Analysis of Benefit Evaluation between Volume-targeted Ventilation and Pressure-limited Ventilation in Preterm Infants
摘要
Abstract
Objective To assess the benefit of volume-targeted ventilation (VTV) compared with pressure-limited ventila-tion (PLV) in preterm infants.Methods The electronic databases of PubMed,the Cochrane Library (Issue 4,2017) andChina National Knowledge Infrastruture (CNKI) were searched from inception to April 1,2017.The literature screen anddata extraction were performed two researchers independently.After evaluating the risk of bias in the study,the RevMan 5.2 software was used for Meta analysis.ResultsFifteen randomized controlled trials and 6 crossover trials were included in atotal of 1427 patients.The Meta analysis results showed that:compared with PLV,VTV can reduce the mortality rate [RR=0.68,95％CI (0.51,0.90),I2=0,P=0.82],reduce bronchial dysplasia [RR=0.73,95％CI (0.60,0.90),I2=25％,P=0.21],shorten the mechanical ventilation time [MD =-2.00,95％CI (-3.14,-0.86),I2 =45％,P=0.07],reduce the intraventricular hemorrhage (IVH) [RR =0.65,95％CI (0.42,0.99),I2 =53％,P=0.02],reduce 3/4 gradeIVH [RR =0.53,95％CI (0.32,0.75),I2 =21％,P=0.27,reduce the periventricular white matter malacia [RR =0.35,95％CI (0.16,0.66),I2 =0,P=0.90],and reduce pneumothorax [RR =0.46,95％CI (0.25,0.86),I2 =0,P=0.85].Corclusior Compared with the traditional ventilation ventilator PLV scheme,VTV schemeof ventilation in the treatment ofpremature infants can significantly reduce the mortality and the incidence of BPD,shorten the time of ventilation and oxygeninhalation,reduce the incidence rate of invalid ventilation,IVH,3/4 grade IVH,hypocapnia,pneumothorax and periven-tricular leukomalacia.Subject to limitations in sample size and research quality,the results above conclusions still need tobe validated by large-scale and high-quality RCTs.关键词
定容通气/压力限定通气/早产儿/Meta分析Key words
Volume-targeted ventilation/Pressure-limited ventilation/Preterm infants/Systematic review引用本文复制引用
王蓓,姚翠婵,石卉..比较定容通气与压力限定通气在早产儿中效益评估的Meta分析[J].湖北医药学院学报,2017,36(4):315-324,10.基金项目
广州市医药卫生科技项目(20171A011255) （20171A011255）
