中国临床药理学杂志2017，Vol.33Issue(17)：1651-1653,3.DOI:10.13699/j.cnki.1001-6821.2017.17.012
西尼地平片治疗原发性高血压的临床研究
Clinical trial of cilnidipine tablets in the treatment of essential hypertension
摘要
Abstract
Objective To observe the clinical efficacy and safety profile of cilnidipine tablets in patients with essential hypertension.Methods A total of 80 patients with essential hypertension were enrolled in this study.The blood pressure and heart rate were recorded in the morning (at the same time everyday) before the treatment.A 3-day average of home blood pressure and heart rate served as the baseline.The blood pressure and heart rate were measured after 2,4,8 weeks treatment and then were compared.Results On the baseline and at 2-week,4-week and 8-week treatment,the clinic systolic blood pressure of the patients were (171.94 ±21.02),(148.19 ± 11.28),(127.20 ±7.28) and (126.98 ±7.52) mmHg;The clinic diastolic blood pressure were (97.91 ± 15.27),(86.44 ± 9.76),(77.85 ± 6.87) and (76.10 ±6.61) mmHg.The clinic heart rates were (76.31 ±9.72),(72.26±7.28),(70.01 ±6.22)and (69.91 ±6.11) beats · min-1 The home systolic blood pressure were (170.13 ± 18.98),(148.37 ± 10.57),(127.52 ± 7.30),(127 ± 7.44) mmHg.The home diastolic pressure were (97.20 ±12.59),(86.65 ±9.26),(77.95 ±6.63),(77.58 ±6.42)mmHg.The home heart rates were (76.05 ± 9.17),(72.15 ± 7.05),(69.98 ±6.15),(69.88 ±6.04) beats · min-1.The effective rate of cilnidipine in the treatment of essential hypertension was 88.89％ (64/72 cases).Statistically significant differences were found in all the parameters above at different time points (P＜0.05).Adverse drug reactions were dizziness (2 cases),hypotension (1 case),facial flushing (1 case),hot flashes (1 case)and heart palpitations (1 case),and the incidence of adverse drug reactions was 7.50％ (6/80 cases).Conclusion Cilnidipine could reduce blood pressure and heart rate effectively in patients with hypertension.关键词
西尼地平/交感神经兴奋性/原发性高血压/心率Key words
cilnidipine/sympathetic hyperfunction/essential hypertension/heart rate分类
医药卫生引用本文复制引用
程爱媛,贺媛,杨培龙..西尼地平片治疗原发性高血压的临床研究[J].中国临床药理学杂志,2017,33(17):1651-1653,3.基金项目
河北省科技计划基金资助项目(142777111D) （142777111D）
