王宏家 1徐丽 1张威 1朱玉辉 1吕游 1田野2
作者信息
- 1. 吉化集团公司总医院骨科,吉林省吉林市132021
- 2. 吉化集团公司总医院麻醉科,吉林省吉林市132021
- 折叠
摘要
Abstract
Objective To observe the effect of different doses of pregabalin and self-control analgesia (PCA) in early postoperative pain in orthopedic lumbar spine surgery patitens.Methods A total of 54 patients with lumbar spinal canal stenosis lumbar vertebrae decompression surgery were randomly divided into high,middle and low dose groups,each group 18 cases.High,middle and low dose groups were orally given pregabalin 300,150,75 mg at 2 h before anesthesia.The patient controlled analgesia (PCA) was used after surgery.The visual analogue score (VAS) at 2,6,12,24 h after surgery,the analgesia drug dosage within 24 h of self-control,incidence of adverse drug reactions were observed in two groups.Results The VAS at 2 h after surgery in high,middle and low dose groups were 3.72 ± 1.27,3.67 ± 1.14,4.78 ± 1.31,with significant difference between high dose and low dose groups(P ＜0.05).The VAS at 6 h after surgery in high,middle and low dose groups were 3.06 ± 0.80,3.28 ± 1.49,4.00 ± 0.69,with significant difference between high dose and low dose groups (P ＜ 0.05).The VAS at 12 h after surgery in high,middle and low dose groups were 2.28 ± 0.67,3.11 ± 1.28,3.33 ± 0.84,with significant difference (P ＜ 0.05).The VAS at 24 h after surgery in high,middle and low dose groups were 2.17 ±0.62,2.83 ± 1.10,2.83 ±0.71,with no significant difference (P ＞0.05).There were 1 case of dizziness,nausea and vomiting,1 case of somnolence,1 case of nausea and vomiting,with the incidence of 16.67％ (3/18 cases).There was 1 case of nausea and vomiting respectively in middle dose and low dose group,with the incidence of 5.56％ (1/18 cases).There was no significant difference in the incidence among three groups (P ＞ 0.05).Conclusion Lyrica drugs prior to application in orthopedic surgery,early postoperative analgesic effect is good,with low incidence of adverse reactions,300 mg of drug delivery in advance can be a good solution.关键词
超前镇痛/普瑞巴林/地佐辛Key words
analgesia in advance/pregabalin/dezocine分类
医药卫生
