中国临床药理学杂志2017，Vol.33Issue(18)：1744-1747,4.DOI:10.13699/j.cnki.1001-6821.2017.18.003
甲泼尼龙片联合吗替麦考酚酯胶囊治疗急性肾损伤的临床研究
Clinical trial of methylprednisolone combined with mycophenolate mofetil capsules in the treatment of acute kidney injury
摘要
Abstract
Objective To evaluate the efficacy and safety of methylprednisolone combined with mycophenolate mofetil in the treatment of acute kidney injury.Methods A total of 72 patients with acute kidney injury were randomly devided into the control group(n =36) and the treatment group (n =36).The control group was orally given mycophenolate mofetil 500 mg,bid;the treatment group was given methylprednisolone 4 mg,tid,on the basis of the control group.Both groups were treated for 2 courses (2 weeks a course).After treatment,the clinical efficacy,the expression of the blood urea nitrogen(BUN),serum creatinine(Scr) and Notch protein at the 3,7,15 d and the incidence of adverse drug reactions (ADR) were compared between the 2 groups.Results After treatment,the total etfective rates of the control group and the treatment group were 69.44％ (25/36) and 88.89％ (32/36),the difference was statistically significant (P ＜0.05).After 3,7,15 d of the treatment,BUN,Scr and Notch protein content index of the treatment group and the control group were significantly lower than before treatment.After treatment,the hemoglobin index in treatment group and control group were(123.46 ± 10.36),(101.37 ± 12.24) g · L-1,KIM-1 (0.34 ± 0.12),(0.93±0.39) ng·mL-1,SOD(72.24_±7.26),(84.86 ±9.71) U·mL-1,MDA(4.05±0.51),(5.36±0.79)nmol · mL-1 respectively,the difference was statistically significant (P ＜ 0.05).There was 1 ease with abnormal liver function,1 case infection,1 case hypertension in the treatment group.There was 1 case with abnormal liver function,2 cases with infection,1 cases with hypertension in the control group.The incidence of adverse drug reactions(ADR) in the treatment group and the control group were 8.33％ (3/36 cases) and 11.11％ (4/36 cases)respectively,the difference was not statistically significant (P ＞ 0.05).Conclusion The curative effect of the methylprednisolone combined with mycophenolate mofetil was better than that of mycophenolate mofetil in the treatment of acute kidney injury,improved the expression level of Notch protein,beneficial to the establishment of Notch/Hes1 signaling pathway and promoted the recovery of serum cytokines.关键词
甲泼尼龙/吗替麦考酚酯/急性肾损伤/Notch/Hes1信号通路Key words
methylprednisolone/mycophenolate mofetil/acute kidney injury/Notch/Hes1 signaling pathway分类
医药卫生引用本文复制引用
黄勤,黄飞..甲泼尼龙片联合吗替麦考酚酯胶囊治疗急性肾损伤的临床研究[J].中国临床药理学杂志,2017,33(18):1744-1747,4.基金项目
湖北省自然科学基金资助项目(2014CFC1066) （2014CFC1066）
