姜黄素对乳腺癌细胞的增殖与迁移及侵袭的影响及其作用机制OA北大核心CSCDCSTPCD
Effect of curcumin on the viavility migration and invasion of breast cancer cells and its mechanism
目的 探讨姜黄素对乳腺癌细胞增殖、迁移及侵袭能力的影响及其作用机制.方法 体外培养乳腺癌细胞MDA-MB-231,对照组分别给予二甲基亚砜(DMSO) 10 μL,处理48 h,低、中、高3个剂量实验组分别给予5,10,20μg·mL-1姜黄素,处理48 h.用四甲基偶氮唑盐(MTT)法检测乳腺癌细胞增殖能力的变化,用TUNEL法检测乳腺癌细胞凋亡的程度;用划痕实验及Transwell侵袭实验分别检测乳腺癌细胞的迁移及侵袭能力,用Western …查看全部>>
Objective To explore the effects and the mechanisms of curcumin on in vitro viability,migration and invasion of human breast cancer cell line.Methods The test group (the concentrations of curcumin were 5,10,20 μg · mL-1,respectively)and control group were set in experiment.The inhibition effect of curcumin on the viability of MDA-MB-231 was determined with methyl thiazolyl tetrazolium (MTT).The apoptosis rate was determined with TUNEL assay.Themigration rate…查看全部>>
王巧琳;何娜娜;陆明;王宁;陈音
新疆医科大学附属中医医院肿瘤一科,乌鲁木齐830000新疆医科大学附属中医医院肿瘤一科,乌鲁木齐830000新疆医科大学附属中医医院肿瘤一科,乌鲁木齐830000新疆医科大学附属中医医院肿瘤一科,乌鲁木齐830000新疆医科大学附属中医医院肿瘤一科,乌鲁木齐830000
医药卫生
姜黄素乳腺癌细胞增殖迁移侵袭
curcuminbreast cancerviabilitymigrationinvasion
《中国临床药理学杂志》 2017 (18)
1793-1796,4
新疆维吾尔自治区自然科学基金资助项目(2016DOIC144)
评论