中国临床药理学杂志2017，Vol.33Issue(18)：1824-1827,4.DOI:10.13699/j.cnki.1001-6821.2017.18.026
姜酚在心血管疾病中的药理作用研究进展
Research progress on pharmacological actions of gingerols in cardiovasular disease
摘要
Abstract
Gingerols are the important active compounds in ginger(Zingiber ocinale Roscoe,Zingiberacae),and 6-gingerol is the main compound of gingerols.Chinese and foreign scholars have done a lot of studies on the molecular structure and pharmacological effects of gingerols and its homologues,which confirmed that gingerols have cardiovascular pharmacological effects of anti-inflammatory,anti-oxidative,anti-hypertensive,cardiac,anti-platelet,hypolipidemic,anti-atherosclerosis and so on.Gingerols play the above pharmacological effects by inhibiting the inflammatory factors,angiotensin Ⅱ activity,cyclooxygenase activity,thromboxane synthesis,the production of advanced glycation end-products;promoting the activity of myocardial sarcoplasmic reticulum Ca2+-ATPase;regulating relate enzyme expression during the process of lipid metabolism and other ways.This article mainly reviews the recent progress in the pharmacological mechanism of gingerols in cardiovascular diseases.关键词
姜酚/抗氧化/抗血小板/抗动脉粥样硬化Key words
gingerols/anti-oxidative/anti-hypertensive/anti-platelet/anti-atherosclerosis分类
医药卫生引用本文复制引用
吴英智,傅强,严全能,李志樑..姜酚在心血管疾病中的药理作用研究进展[J].中国临床药理学杂志,2017,33(18):1824-1827,4.基金项目
国家自然科学基金资助项目(81573732) （81573732）
广东省自然科学基金资助项目(2015A030313304) （2015A030313304）
