中国临床药理学杂志2017，Vol.33Issue(18)：1828-1831,4.DOI:10.13699/j.cnki.1001-6821.2017.18.027
Wnt信号通路与心肌纤维化的研究进展和应用前景
Progress and potential directions of Wnt signaling in cardiac fbrosis
摘要
Abstract
Myocardial fibrosis (MF) is a common pathologic change in the development of a variety of heart diseases to a certain stage and is one of the major manifestations of myocardial remodeling.This pathological changes exist in a variety of cardiovascular diseases,and arrhythmia,heart failure and other diseases are closely related.Wnt signaling pathway has the biological function of regulating cell growth,autophagy,proliferation and apoptosis.Wnt can regulate the activation of cardiac fibroblasts(CFS) and the deposition of extracellular matrix(ECM),which plays an important role in the development of myocardium fibrosis(MF).The Wnt signaling pathway suppresses CFS activation and ECM deposition by antagonizing the abnormal activation of the Wnt signaling pathway,suggesting that regulation of Wnt pathway signaling may become a potential MF therapeutic target.This article mainly on the Wnt signal pathway and myocardial fibrosis for a review,for the clinical treatment to provide a new direction.关键词
心肌纤维化/抑制剂/治疗靶点Key words
cardiac fibrosis/inhibitor/therapeutic target分类
医药卫生引用本文复制引用
李娇,赵信科,魏惠平,刘斌,王志鹏,李应东..Wnt信号通路与心肌纤维化的研究进展和应用前景[J].中国临床药理学杂志,2017,33(18):1828-1831,4.基金项目
甘肃省自然科学基金资助项目(1508RJZA015) （1508RJZA015）
