中国实用外科杂志2017，Vol.37Issue(9)：1032-1034,1038,4.DOI:10.19538/j.cjps.issn1005-2208.2017.09.22
细针穿刺甲状腺球蛋白检测对甲状腺乳头状癌颈淋巴结转移诊断价值探讨
The diagnosis value of fine-needle aspiration thyroglobulin testing in cervical lymph node metastasis of papillary thyroid carcinoma
杨汶士 1张艳 1龙厚隆 1张凤凤 1王思雷 1刘斌 1李峰1
作者信息
- 1. 滕州市中心人民医院乳腺甲状腺外科,山东滕州277500
- 折叠
摘要
Abstract
Objective To investigate the value of fine needle aspiration thyroglobulin (FNAB-Tg) testing in cervical lymph node metastasis of papillary thyroid carcinoma.Methods A total of 41 patients with thyroid cancer underwent surgical treatment from September 2013 to September 2015 in the Central People's Hospital of Tengzhou.Intraoperative rapid pathologically confirmed PTC parallel neck dissection was performed.A total of 152 lymph nodes from dissection specimens were arbitrarily selected to fine needle aspiration biopsy,then biopsy needle content was expelled onto a slide and smeared using a second slide,which were read by an experienced cytopathologist.Another biopsy tissue was repeatedly washed with 0.5mL of normal saline in EP tube,using ECLIA quantitative Tg.The dissected nodes were send to histopathologic diagnosis as the gold standard.The value of the two methods were compared in the diagnosis of cervical lymph node metastasis of thyroid cancer.PTC patients were divided into positive and negative groups based on values of serum thyroglobulin antibody (serum thyroglobulin antibodies,S-TgAb).The impact of S-TgAb to FNAB-Tg was analyzed comparatively.Results The sensitivity,specificity and the diagnosis accurate rate of cervical lymph node metastasis in thyroid cancer diagnosis by FNAB-Tg were 95.3％,95.5％,95.4％,respectively.Those of fine needle aspiration cytology (FNAC) were 84.4％,86.4％,85.5％,respectively.The difference had significance statistically.The influence of S-TgAb on FNAB-Tg diagnosis of cervical lymph node metastasis displayed P=0.415 ＞ 0.05,and the difference had not significance statistically.Conclusion FNA-Tg can improve the diagnostic accuracy of PTC lymph node metastasis,and is not affected by S-TgAb,which can be widely used in clinic to determine the staging and treatment programs of thyroid cancer.关键词
甲状腺乳头状癌/细针穿刺/细胞学/甲状腺球蛋白Key words
papillary thyroid carcinoma/fine needle aspiration/cytology/thyroglobulin分类
医药卫生引用本文复制引用
杨汶士,张艳,龙厚隆,张凤凤,王思雷,刘斌,李峰..细针穿刺甲状腺球蛋白检测对甲状腺乳头状癌颈淋巴结转移诊断价值探讨[J].中国实用外科杂志,2017,37(9):1032-1034,1038,4.
