中国医学前沿杂志（电子版）2017，Vol.9Issue(8)：63-66,4.DOI:10.12037/YXQY.2017.08-13
前列地尔对急性心肌梗死患者左室重构的影响
The effect of Alprostadil on left ventricular remodeling in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the effect of Alprostadil on left ventricular remodeling in patients with acute myocardial infarction. Method 152 patients with acute myocardial infarction in our hospital from June 2015 to June 2016 were randomly selected and divided into control group and observation group, 76 cases in each group. Two groups of patients were treated with conventional coronary heart disease, observation group patients were treated with Alprostadil on the basis of the above treatment, continuous treatment for 21 days. Before and after 7 days and 21 days treatment, the left ventricular end systolic diameter (LVESd), left ventricular end diastolic diameter (LVEDd), left ventricular posterior wall end diastolic diameter (LVPWd), ejection fraction (EF), early diastolic atrial maximum velocity (E peak) and atrial systolic peak filling rate (A peak) and the effect of velocity ratio (E/A) were detailed recorded and compared between the two groups. The curative effect was counted 21 days after treatment. Result After 7 days and 21 days treatment, the LVEDd and LVESd of the two groups were significantly less than those before treatment (P<0.05). The LVEDd and LVESd in observation group were significantly less than control group (P<0.05). There was no significant changes of LVPWd between the two groups before and after treatment (P>0.05). After treatment for 7 days and 21 days, the EF of observation group was significantly lower than control group (P<0.05), the curative effect and E/A were significantly higher than control group (P<0.05). Conclusion The use of Alprostadil in the treatment of acute myocardial infarction can effectively reduce the levels of the LVEDd, LVESd, EF, improve E/A and curative effect, reduce left ventricular remodeling, improve cardiac function.关键词
急性心肌梗死/前列地尔/左室重构Key words
Acute myocardial infarction/Alprostadil/Left ventricular remodeling引用本文复制引用
吴小燕,刘先霞,吴曾繁,吴学正,赵勇,张远生..前列地尔对急性心肌梗死患者左室重构的影响[J].中国医学前沿杂志（电子版）,2017,9(8):63-66,4.基金项目
2014年海南省卫生厅项目(琼卫2014-48) （琼卫2014-48）
