中国卒中杂志2017，Vol.12Issue(10)：895-899,5.DOI:10.3969/j.issn.1673-5765.2017.10.003
幽门螺杆菌感染及同型半胱氨酸与急性缺血性卒中短期结局的相关性研究
The Study on Correlation between Helicobacter Pylori Infection, Homocysteine and Short-term Outcome of Acute Ischemic Stroke
摘要
Abstract
Objective To study the relationship between Helicobacter pylori (Hp) infection, homocysteine (Hcy) and short-term outcome of acute ischemic stroke (AIS). Methods A prospective cohort study was conducted. A total of 120 patients with primary-acute ischemic stroke were enrolled in Tangshan Gongren hospital. The Hp-IgG and Hcy levels were measured, and the National Institutes of Health Stroke Scale (NIHSS) was performed after admission, and other related factors (including general clinical data and biochemical indexes) were collected. Modified Rankin Scale (mRS) at Month 2 after onset was performed when the patients were in admission and at discharge. Results (1) The Hp infection rate and the Hcy level of the poor-outcome group were higher than that in good-outcome group, and the difference was statistically significant (P<0.05). (2) Univariate logistic regression analysis showed that age, sex, NIHSS score, Hcy level and Hp infection were associated with short-term outcome of AIS patients. (3) Multivariate logistic regression showed age (OR=1.021,P=0.017), NIHSS Score (OR=2.318,P<0.001), Hp infection (OR=1.038,P=0.008), Hcy(OR=1.029,P<0.001)were correlated with short-term outcome of acute ischemic stroke. Conclusion Hp infection and elevated homocysteine level were the risk factors for short-term outcomes in patients with acute ischemic stroke.关键词
急性缺血性卒中/幽门螺杆菌/同型半胱氨酸/预后/危险因素Key words
Acute ischemic stroke/Helicobacter pylori/Homocysteine/Prognosis/Risk factors引用本文复制引用
刘舒,李永秋,夏立伟,赵明艳,李瑜霞,徐明,郭鑫,刘玉兰..幽门螺杆菌感染及同型半胱氨酸与急性缺血性卒中短期结局的相关性研究[J].中国卒中杂志,2017,12(10):895-899,5.基金项目
唐山市科技计划项目(13130260b) （13130260b）
