光学精密工程2017，Vol.25Issue(9)：2277-2282,6.DOI:10.3788/OPE.20172509.2277
水凝胶支架的飞秒激光全息加工
Femtosecond laser holograpic fabrication of hydrogel cell scaffold
摘要
Abstract
In order to achieve rapid fabrication of hydrogel cell scaffolds , the computer-aided holographic method was employed into the traditional femtosecond laser two-photon processing .The generation of hologram as well as the influence of its parameters on the processed cylinder microstructure was studied .Firstly ,Ring-shaped Bessel-beam holograms were generated according to the Bessel light wave equation and its transmission function ,of which the parameters' effect on the size and quality of ring structure was analyzed .Then the generated holograms were used to process tubes with a thickness of 0 .8 μm and diameters from 8 μm to 15 μm in the polyethylene glycol double acrylate (PEGDA ) hydrogel .Finally ,an efficient and rapid processing of hydrogel cell scaffolds was realized experimentally and the diameter of hydrogel tubes was 8 μm .This technique can remarkably improve the efficiency of femtosecond laser processing ,thus has great potential in many applications such as biological culture and chemical analyses .关键词
飞秒激光/双光子加工/贝塞尔光束/水凝胶/细胞支架Key words
femtosecond laser/two-photon processing/Bessel beam/hydrogel/cell scaffold分类
信息技术与安全科学引用本文复制引用
潘登,李家文,杨亮,胡衍雷,吴东,黄文浩,褚家如..水凝胶支架的飞秒激光全息加工[J].光学精密工程,2017,25(9):2277-2282,6.基金项目
国家自然科学基金资助项目(No.51675503,No.61475149,No.51405464,No.61675190,No.51605463) （No.51675503,No.61475149,No.51405464,No.61675190,No.51605463）
中央高校基本研究经费资助项目(No.WK2480000002) （No.WK2480000002）
中国博士后科学基金资助项目(No.2016M590578,No.2016M602027) （No.2016M590578,No.2016M602027）
中科院仪器研制项目(No.YZ201566) （No.YZ201566）
