中国实用神经疾病杂志2017，Vol.20Issue(17)：4-6,3.DOI:10.3969/j.issn.1673-5110.2017.17.002
乌司他丁对脑缺血再灌注大鼠脑组织JNK及细胞凋亡的影响
Effects of ulinastatin on the expression of c-Jun N-terminal kinase and apoptosis in rats with cerebral ischemia-reperfusion injury
刘庆杰 1白宏英2
作者信息
- 1. 永城市人民医院神经内科,河南永城476600
- 2. 郑州大学第二附属医院神经内科,河南郑州450014
- 折叠
摘要
Abstract
Objective To investigate the effects of ulinastatin on the expression of c-Jun N-terminal kinase (JNK) and apoptosis in rats with cerebral ischemia-reperfusion injury.Methods Thirty-six male clean SD rats were divided into three groups by the random number method:sham operation group (SO group,n =12),cerebral ischemia-reperfusion group (I/R group,n =12),cerebral ischemia-reperfusion plus ulinastatin treatment group (treatment group,n =12).The focal cerebral ischemia-reperfusion injury models were established by using suture-occluded method to block middle cerebral artery.The expression of JNK was detected by using RT-PCR method and the number of apoptosis was detected by TUNEL method.Results Compared with the SO group,the treatment group and control group showed high expression of JNK on cortex area and high number of apoptosis (all P ＜0.05).Both the expression of JNK and the number of apoptosis in the treatment group were significantly less than those in the control group (all P＜0.05).Conclusion Ulinastatin can down-regulate the expression of JNK in brain tissues and can suppress apoptosis which may be related to inhibit JNK conduction path.关键词
乌司他丁/脑缺血再灌注/c-Jun氨基末端激酶/细胞凋亡Key words
Ulinastatin/Ischemia-reperfusion/C-Jun N-terminal kinase/Apoptosis分类
医药卫生引用本文复制引用
刘庆杰,白宏英..乌司他丁对脑缺血再灌注大鼠脑组织JNK及细胞凋亡的影响[J].中国实用神经疾病杂志,2017,20(17):4-6,3.
