摘要
Abstract
Objective Detection of macular ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness in patients with neuromyelitisoptica spectrum disorders(NMOSD) and multiple sclerosis(MS) by optical coherence tomography (OCT),and to evaluate the optic nerve and axon impairment of MS and NMOSD.Methods This is a retrospective controlled study.30 cases of MS patients were enrolled as MS group,32 cases of NMOSD patients were enrolled as NMOSD group,and 30 cases of healthy people in contemporaneity were enrolled as control group.All groups were detected for the two quadrants (superior,inferior) and average of GCC thickness and the four quadrants (superior,inferior,nasal,temporal) and average of pRNFL thickness via OCT.All data were compared and analyzed statistically.Results The all quadrants and average of GCC and RNFL thickness were thinner in the MS,NMOSD group compared with control group(P＜0.05).The all quadrants and average of GCC thickness in NMOSD group were thinner than those of MS group (P ＜ 0.05).The RNFL thickness of superior quadrants of NMOSD group was thinner than that of MS group(P ＜0.05),but there was no significant difference of RNFL thickness in the rest of the quadrants(inferior,nasal,temporal) and average between NMOSD group and MS group(P＞0.05).Conclusion There are optic nerve and axon impairment in NMOSD and MS patients,but the impairment in NMOSD patients were more severe.关键词
视神经脊髓炎谱系疾病/多发性硬化/光学相干断层成像/神经节细胞复合体/视网膜神经纤维层Key words
neuromyelitisoptica spectrum disorders/multiple sclerosis/optical coherence tomography/macular ganglion cell complex/retinal nerve fiber layer分类
医药卫生
