摘要
Abstract
Objective To evaluate the effect of low dose rt-PA combined with urokinase on vertebrobasilar system cerebral infarction.Methods Totally 100 patients with vertebrobasilar system cerebral infarction,were randomly divided into combination group,rt-PA group,urokinase group and control group,25 cases in each group.The national institutes of health stroke scale(NIH-SS) score,activities of daily living(ADL) score,clinical efficacy,cerebral hemorrhage rate and re-infarction rate were compared between the two groups.Results After treatment,the NIHSS score of each group were significantly lower than before treatment (P＜0.05),and the NIHSS score of combination group,rt-PA group and urokinase group were significantly lower than control group(P ＜0.05),but were no statistical difference between combination group,rt-PA group and urokinase group(P ＞0.05).After treatment,the ADL score of each group were significantly higher than before treatment(P＜20.05),and the NIHSS score of combination group,rt-PA group and urokinase group were significantly higher than control group (P ＜ 0.05),but were no statistical difference between combination group,rt-PA group and urokinase group(P＞0.05).The clinical efficacy of combination group,rtPA group and urokinase group were significantly higher than control group(P＜0.05),but were no statistical difference between combination group,rt-PA group and urokinase group (P ＞ 0.05).The re-infarction rate between each group were no statistical difference(P ＞0.05).The cerebral hemorrhage rate of combination group significantly lower than rt-PA group and urokinase group(P＜0.05).Conclusion Low dose rt-PA combined with urokinase treat with vertebrobasilar system cerebral infarction is effective and safe,and can effectively reduce cerebral hemorrhage rate.关键词
椎基底动脉系统/脑梗死/静脉溶栓/rt-PA/尿激酶Key words
Vertebrobasilar system/Cerebral infarction/Intravenous thrombolysis/rt-PA/Urokinase分类
医药卫生
