解放军医学杂志2017，Vol.42Issue(10)：848-853,6.DOI:10.11855/j.issn.0577-7402.2017.10.02
呼吸道病毒与气道上皮细胞的免疫调控
Immunoregulation by airway epithelial cells (AECs) against respiratory virus infection
摘要
Abstract
The respiratory tract is primary contact site of the body and environment,and it is ventilated by 10-20 thousand liters of air per day.Inevitably,the respiratory system comes into contact with airborne microbes,which contain the disease-causing pathogens.Airway epithelial cells (AECs) are known to have innate sensor functions,which are similar to the "professional" immune cells,such as alveolar macrophage and sub-or intra-epithelial dendritic cells (DCs).Thus AECs are able to detect invading microbial danger including different types of respiratory viruses,and mount a potent host response,for example,activating type Ⅰ interferon signaling pathway genes.To avoid chronic inflammation and maintain the immunological homeostasis,the pulmonary system has developed intrinsic mechanisms to control local immune responses.Most recently,the role of AECs in control of local immunity has gained much attention,as 1) AECs express the pattern recognition receptors (PRRs),such as Toll-like receptors,retinoic acid inducible gene Ⅰ (RIG-Ⅰ)-like receptor,and so on,thus AECs are equipped to Participate in innate detection of microbial encounter;2) To keep immunological homeostasis in the respiratory tract,AECs behave not only as innate immune sensors but also as immune modulators in parallel,through modulating the sensitivity of innate immune sensing of both AECs per se and sub-or intra-epithelial immune cells;3) Loss of modularity capacity of AECs might be involved in the development of chronic airway diseases.In present review,how the AECs act will be intensively discussed in response to respiratory viruses and modulate the local immunity through cis-and trans-factors (direct and indirect factors),as well as the consequence of impairment of this control of local immunity,in the development and exacerbation of airway diseases,such as acute and chronic rhinosinusitis.关键词
气道上皮细胞/呼吸道病毒/天然免疫/免疫稳态/气道炎症性疾病Key words
airway epithelial cells/respiratory viruses/innate immunity/immunological homeostasis/inflammatory airway diseases分类
医药卫生引用本文复制引用
严彦,王昭妮,洪海裕,陈锴升,王筱惠,Luukkainen Annika,Chow Vincent TK,王德云..呼吸道病毒与气道上皮细胞的免疫调控[J].解放军医学杂志,2017,42(10):848-853,6.基金项目
新加坡卫生部医学研究项目(NMRC/CIRG/1362/2013,NMRC/CIRG/1458/2016) （NMRC/CIRG/1362/2013,NMRC/CIRG/1458/2016）
中山大学“百人计划”引进人才科研启动基金.This work was supported by the National Medical Research Council,Singapore (NMRC/CIRG/1362/2013,NMRC/CIRG/1458/2016) and the Start-up Grant for Top 100 Talent Program of Sun Yat-sen University （NMRC/CIRG/1362/2013,NMRC/CIRG/1458/2016）
