解放军医学杂志2017，Vol.42Issue(10)：883-886,4.DOI:10.11855/j.issn.0577-7402.2017.10.08
颈动脉冷盐水灌注对低温性心脏骤停复苏犬模型的神经保护作用
Neuroprotective effect of intracarotid cold saline infusion following cardiopulmonary resuscitation in a hypothermic cardiac arrest canine model
摘要
Abstract
Objective To evaluate the effect of intracarotid cold saline infusion (ICSI) on neurological outcomes in canines with cardiac arrest (CA) introduced by severe hypothermia.Methods Restoration of spontaneous circulation (ROSC) after hypothermic CA was induced in 10 Beagle dogs.These 10 dogs were randomly divided into 2 groups (5 each).Dogs in control group were rewarmed using warn water bath,and dogs in experimental group received the bath rewarming plus ICSI for 6 hours to maintain the brain temperature ＜36℃.In both groups,the Neurologic Disability Scores (NDS) were recorded at 24h after the ROSC,and their brains were removed for pathologic analysis using hematoxylin and eosin stain.The brain water content and sl00β of serum level were also measured.Results The water content (79.43％ ± 0.72％ vs.80.79％ ± 1.06％,P＜0.05) and serum level of s100β (119.83 ± 42.93pg/ml vs.329.82 ± 190.39pg/ml,P＜0.05) were significantly lower in experimental group than in the control group.Control group presented obvious pathological damage of the hippocampal pyramidal cells.There was no significant difference in NDS between the two groups.Conclusion ICSI could reduce the production of s100β and pathological brain damage in postarrest hypothermic canines.关键词
心脏停搏/心肺复苏/颈动脉输注/亚低温Key words
cardiac arrest/cardio-pulmonary resuscitation/intracarotid infusion/mild hypothermia分类
医药卫生引用本文复制引用
帅维正,袁瑞,张志成,段蕴铀..颈动脉冷盐水灌注对低温性心脏骤停复苏犬模型的神经保护作用[J].解放军医学杂志,2017,42(10):883-886,4.基金项目
全军医学科技青年培育项目(14QNP059).This work was supported by the Medical Science and Technology Supporting Program of PLA(14QNP059) （14QNP059）
