解放军医学杂志2017，Vol.42Issue(10)：920-924,5.DOI:10.11855/j.issn.0577-7402.2017.10.15
肝脏移植术后体液性排斥反应的研究进展
Research progress on humoral rejection after liver transplantation
摘要
Abstract
Recent studies have shown that humoral rejection,or antibody-mediated rejection (AMR),is an important risk factor for graft failure.Transplant experts have accumulated some experience on the diagnosis and treatment of AMR after kidney transplantation.However,AMR after liver transplantation has not been fully understood until recently,and its pathogenesis,clinical manifestation,diagnosis and treatment are different from AMR after kidney transplantation.In the research progress,the AMR after liver transplantation was classified into hyper acute rejection,acute humoral rejection,chronic humoral rejection and the state of accommodation.The immunity mechanism of AMR after liver transplantation is also described.The different kinds of AMR after liver transplantation were diagnosed by analyzing the clinical manifestations,serum tests and pathological characteristics of the patients.Moreover,the risk factors of them were mentioned in the article.Then we also introduce the different strategies for prevention and treatment of AMR after liver transplantation.Therefore,based on the current research progress on AMR after liver transplantation,we analyze the future direction of progress.关键词
肝移植/体液免疫/排斥反应Key words
liver transplantation/humoral immune/allograft rejection分类
医药卫生引用本文复制引用
徐春扬,宋少华,丁国善..肝脏移植术后体液性排斥反应的研究进展[J].解放军医学杂志,2017,42(10):920-924,5.基金项目
国家自然科学基金(81671576) （81671576）
上海市卫生和计划生育委员会课题(201640274).This work was supported by the National Natural Science Foundation of China (81671576),and Shanghai Health and Family Planning Commission Foundation (201640274) （201640274）
