检验医学与临床2017，Vol.14Issue(21)：3148-3151,4.DOI:10.3969/j.issn.1672-9455.2017.21.006
泸州地区健康成人糖化血红蛋白一致性参考区间的建立及验证
Development and validation of consistency reference interval for hemoglobin HbA 1c in healthy adults in Luzhou area
摘要
Abstract
Objective To develop the consistency reference interval for hemoglobin A 1c(HbA1c) in healthy adults in Luzhou ar-ea and verify its applicability .Methods Seven clinical laboratories that represent the region′s geographical area were chosen ,4163 healthy individuals were recruited in 7 hospitals from May 2012 to June 2014 according to unified inclusion criteriaand the total number of healthy individualswere not less than 500 people in every hospital .All selected healthy individuals were divided into male and female groups ,then two groups were divided into ≤44 years old(young group) ,>44-59 years old (middle-aged group) ,>59 years old (elderly group)in accordance with their age .HbA1c and serum biochemical indexes of all individuals were detected . Results The difference of serum biochemical indexes among the laboratories werenot significant ,which complied with their quire-ments of hemoglobin HbA1c reference interval .The difference of HbA1c among the same group in different laboratories were not significant (P>0 .05) ,then same group data of HbA1c among 7 laboratories were merged ,and the merged data were performed by multi-independent samples Kruskal-Wallis test ,the results showed that the difference among 6 groups were significant (χ2 =28 .079 ,P< 0 .05) .All samples were tested by Spearman correlation analysis ,there was not significant correlation between the HbA1c data and gender ,thus there was poor correlation between the HbA 1c data and age (r=0 .253 ,P<0 .05) .Consequently ,con-sistency reference interval for hemoglobin HbA1c in healthy adults in our area was developed ,young group was 4 .40% -6 .30% , middle-aged group and elderly group were 4 .70% -6 .50% ,and their′s applicability were verified by 7 laboratories .Conclusion The consistency reference interval for HbA1c in healthy adults in Luzhou area could be suggested as young group was 4 .40% -6 .30% ,middle-aged group and elderly group were 4 .70% -6 .50% .关键词
糖化血红蛋白/参考区间/多中心Key words
HbA1c/reference interval/multicenter引用本文复制引用
郭永灿,张帮林,杨清明,刘靳波,黎金凤,陈坚,蒋春阳,陈美舟..泸州地区健康成人糖化血红蛋白一致性参考区间的建立及验证[J].检验医学与临床,2017,14(21):3148-3151,4.基金项目
四川省卫生和计划生育委员会基金资助项目(100206 ). （100206 ）
