日用化学工业2017，Vol.47Issue(10)：573-577,5.DOI:10.13218/j.cnki.csdc.2017.10.008
不同剂型四氢姜黄素皮肤渗透性的研究
Study on the cutaneous permeation of tetrahydrocurcumin in various formulations
摘要
Abstract
The permeability of tetrahydrocurcumin (THC ) was studied through experiments in vitro percutaneous. The cumulative permeation rates (CPRs)and retention rates (RRs)in 50% aqueous ethanol, emulsion,solid lipid nanoparticles,and in which before and after adding azone were all determined by high performance liquid chromatography (HPLC ). Results show that the CPRs and RRs of THC increase with permeation time. Its permeability is the strongest in 50% aqueous ethanol,and the weakest in emulsion. After adding azone,the enhancing permeation effect is the most remarkable in 50% aqueous ethanol and the least remarkable in emulsion. Comparing with no azone at the same permeation time,the CPRs in all formulations are improved significantly,and the RRs show no significant change.关键词
化妆品功效成分/四氢姜黄素/高效液相色谱法/累积透过率/滞留率Key words
cosmetic ingredient/tetrahydrocurcumin/HPLC/cumulative permeation rate/retention rate分类
化学工程引用本文复制引用
叶凤,肖伟莉,文国锦,杨兴东,王雪梅..不同剂型四氢姜黄素皮肤渗透性的研究[J].日用化学工业,2017,47(10):573-577,5.基金项目
安徽省绿色高分子材料重点实验室资助项目(kf2012006) （kf2012006）
