陕西师范大学学报（自然科学版）2017，Vol.45Issue(5)：117-124,8.DOI:10.15983/j.cnki.jsnu.2017.05.255
有氧运动和锁阳多糖干预对糖尿病大鼠主动脉舒张功能的影响及其机制研究
The effect of aerobic exercise and Cynomorium Songaricum Polysaccharide intervention for dilatation function of aorta in diabetes rats and involved mechanisms
摘要
Abstract
The effects of exercise training and Cynomorium Songaricum Polysaccharide (CSP) on dilatation function of aorta and involved mechanisms in diabetes rats are discussed.Rats were randomly assigned to the following experimental groups:control group,diabetes group,diabetes +exercise group,diabetes+CSP group.At the end of 8 weeks,measure aortic functions,microstructure and ultrastructure.Immunochemical streptavidin-biotin complex staining and western blot were used to test the distribution and expression of endothelial nitricoxide synthase (eNOS),Akt kinases (Akt) and tumor necrosis growth factor α (TNF-α).These results demonstrated that diabetes degradation of endothelial cells and downregulation the expression of Akt and eNOS,upregulation the expression of TNF-α maybe the factors that decreased the dilatation function of aorta,exercise training and CSP intervention restored the dilatation function of aortic artery may by decreased the injure of endothelial cells,upregulation the expression of Akt and eNOS,downregulation of the expression of TNF-α.关键词
糖尿病/有氧运动/锁阳多糖/主动脉/内皮功能Key words
diabetes/aerobic training/Cynomorium Songaricum Polysaccharide/aorta/endothelial function分类
社会科学引用本文复制引用
王友华,田振军..有氧运动和锁阳多糖干预对糖尿病大鼠主动脉舒张功能的影响及其机制研究[J].陕西师范大学学报（自然科学版）,2017,45(5):117-124,8.基金项目
国家自然科学基金(81570449,31371199) （81570449,31371199）
