山西医科大学学报2017，Vol.48Issue(10)：1044-1047,4.DOI:10.13753/j.issn.1007-6611.2017.10.014
kshv-mir-k12-1-5p相关基因在卡波西肉瘤中的表达
Expression of kshv-mir-k12-1-5p-related gene in Kaposi's sarcoma
摘要
Abstract
Objective To explore the expression of kshv-mir-k12-1-5p-related gene in Kaposi's sarcoma (KS) and its significance.Methods The kshv-mir-k12-1-5p target gene was detected through Mirbase,Miranda and Targetscan of the online miRNA target gene software.GO and KEGG were used to analyze signaling pathway and key gene in the pathway of the target gene.The expression of target gene and key gene(kshv-mir-k12-1-5p-related gene) was detected in Kaposi's sarcoma by immunohistochemistry.Results The target gene of kshv-mir-k12-1-5p was CDKN1A,CDKN1A signaling pathway was the cell cycle pathway,and the downstream key genes were CyclinD1 and CyclinE.Positive expression rate of CDKN1A in KS was lower in tumor tissues than that of adjacent tissues(P ＜ 0.05).Positive expression rates of CyclinD1,CyclinE in KS were higher in tumor tissues than that of adjacent tissues (P ＜ 0.05).Expression of CyclinD1 in KS was associated with age (P ＜ 0.05).Expression of CyclinE in KS was associated with nation (P ＜ 0.05).There was a negative correlation between the expression of CDKN1A and CyclinD1,CyclinE in KS (P ＜ 0.05).There was a positive correlation between the expression of CyclinD1 and CyclinE in KS(P ＜ 0.05).Conclusion The expression of kshv-mir-k12-1-5p-related genes CDKN1A,CyclinD1,and CyclinE may play an important role in the occurrence and development of KS.关键词
卡波西肉瘤/kshv-mir-k12-1-5p/CDKN1A/CyclinD1/CyclinEKey words
Kaposis sarcoma/kshv-mir-k12-1-5p/CDKN1A/CyclinD1/CyclinE分类
医药卫生引用本文复制引用
张静,吴秀娟,普雄明..kshv-mir-k12-1-5p相关基因在卡波西肉瘤中的表达[J].山西医科大学学报,2017,48(10):1044-1047,4.基金项目
国家自然科学基金资助项目(81660454) （81660454）
新疆医科大学附属中医医院院级课题(ZYY201702) （ZYY201702）
