实用妇产科杂志2017，Vol.33Issue(10)：764-768,5.
肿瘤浸润淋巴细胞在浆液性卵巢癌的临床病理分析
Clinicopathological Characteristics of Tumor Infiltrating Lymphocytes in Ovarian Serous Adenocarcinoma
摘要
Abstract
Objective:To investigate the clinicopathological characteristics and immunohistochemical features of tumor-infiltrating lymphocyte(TIL) in ovarian serous adenocarcinoma,and their clinical value.Methods:The immunohistochemistry was used to observe 68 ovarian serous adenocarcinomacases'immunohistochemical features,and their correlations with clinicopathological characteristics were analyzed.Results:There were 43 cases with a large amount of TIL infiltrating in the 68 cases of serous adenocarcinoma,account for 63.24％.There were significant differences on the with or without a large amount of TIL infiltrating among the different tumor grade,different clinical stage,and different CA125 level (P ＜ 0.05).The numbers of CD3 +,CD4 + and CD8 + TIL in the cancer nest were significantly less than those in the stroma,with significantly statistical difference (P ＜ 0.05),Meanwhile the ratio of CD4 +/CD8 + in the cancer nest was significantly less than that in the stroma(P＜0.05).The ratio of CD4 +/CD8 + in the cancer nest and stroma at stage Ⅲ and with poor differentiation was significantly lower than in those at stage Ⅰ-Ⅱ and with good differentiation(P＜0.05).Meanwhile the ratio of CD8 +/FoxP3 + Treg in the cancer nest was less than that in the stroma(P＜0.05).The ratio of CD8 +/FoxP3 + Treg in the cancer nest at stage Ⅲ and with poor differentiation tumor was significantly lower than in those at stage Ⅰ-Ⅱ and with good differentiation(P＜0.05).The expression of GzmB in the cancer nest at stage Ⅲ and with poor differentiation tumor was significantly lower than that in the cancer nest at stage Ⅰ-Ⅱ and with good differentiation tumor(P＜0.05).Conclusions:With or without a large amount of TIL is related to tumor grade,clinical stage,and CA125 level inovarian serous adenocarcinoma.The numbers of TIL in ovarian serous adenocarcinoma increase considerably,but mainly in the stroma,and which may be related to several factors such as tumor cell differentiation and clinical stage.关键词
浆液性卵巢癌/肿瘤浸润淋巴细胞/免疫组化/临床病理Key words
Ovarian serous adenocarcinoma/Tumor-infiltrating lymphocyte/Immunohistochemistry/Clinic pathology分类
医药卫生引用本文复制引用
胡喜珍,丁杰,梁常艳..肿瘤浸润淋巴细胞在浆液性卵巢癌的临床病理分析[J].实用妇产科杂志,2017,33(10):764-768,5.基金项目
广州市医药卫生科技项目(编号:20141A011022) （编号:20141A011022）
广东省科技计划项目(编号:2016A020215074) （编号:2016A020215074）
广东省医学科研基金(编号:A2016060) （编号:A2016060）
