深圳大学学报（理工版）2017，Vol.34Issue(5)：451-456,6.DOI:10.3724/SP.J.1249.2017.05451
羟基磷灰石-壳聚糖复合膜旋涂法制备及表征
Preparation and characterization of hydroxyapatite-chitosan composite coatings using a spin-coating technique
摘要
Abstract
Based on a chemical precipitation method,the hydroxyapatite powders were prepared using Na2HPO4 and Ca (NO3)2 ·4H2O as raw materials.The powders were dispersed into chitosan-acetic acid solution with the aid of continuous ultrasonic agitation to prepare hydroxyapatite-chitosan (HA-CS) suspension via solution blending and magnetic stirring.Hydroxyapatite-chitosan composite coatings were fabricated on 304-type stainless steel substrates by a spin-coating technique,then dried at 25 ℃ and 37 ℃ for 12 h,respectively.The two synthesized samples were characterized and tested by X-ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR),scanning electron microscopy (SEM),energy-dispersive X-ray spectroscopy (EDX) and electronic tensile machine.The results indicate the tensile strength of HA-CS composites reaches up to (69.04 + 1.21) MPa,and the coatings display good crystallinity,good adhesion,high purity and little decomposition.In addition,by means of spin-coating technique,HA could be evenly dispersed in CS and there are no aggregated or free HA particles in the coatings.The HA-CS composite coatings show better performance when drying at 37 ℃ than at 25 ℃,which is more conducive to combine interaction between HA and CS.关键词
生物材料学/羟基磷灰石/壳聚糖/复合膜/旋涂法/力学性能Key words
biomaterials science/hydroxyapatite/chitosan/composite coatings/spin-coating technique/mechanical property分类
医药卫生引用本文复制引用
袁秋华,张自强,徐安平,巫剑波,秦草坪,陈泽汇,林松鑫,张培新..羟基磷灰石-壳聚糖复合膜旋涂法制备及表征[J].深圳大学学报（理工版）,2017,34(5):451-456,6.基金项目
国家自然科学基金资助项目(21471102) （21471102）
深圳市科技基础研究计划资助项目(JCYJ20150525092941007)National Nature Science Foundation of China (21471102) （JCYJ20150525092941007）
Shenzhen Science and Technology Basic Research Foundation (JCYJ20150525092941007) （JCYJ20150525092941007）
