天津中医药2017，Vol.34Issue(11)：778-781,4.DOI:10.11656/j.issn.1672-1519.2017.11.17
异槲皮苷对db/db小鼠肝脏脂肪酸代谢及相关基因表达的影响
Improvement of Isoquercitrin on liver fatty acid metabolism-related gene expression in db/db mice
摘要
Abstract
[Objective] To investigate the effects and mechanisms of Isoquercitrin on liver fatty acid metabolism. [Methods] The 8 week old male db/db mice were randomly divided into two groups, control group and Isoquercitrin group. The 6 male C57BL/6J mice were used as normal group. Examinations were performed, including body weight, serum glucose, lipid, histopathology and expression of mRNA after a 4-weektreatment period. [Results] Compared with the Control group, Isoquercitrin group body weight, FBG, CHO, TG, FFA, liver weight, liver weight/body weight of mice decreased significantly (P<0.05 or P<0.01), and improved fat deposition of liver tissue by histological examination. The expression of SREBP1c, FAS mRNA in liver of Isoquercitrin group decreased (P<0.05 or P<0.01), PGC1α, PPARαmRNA expression was significantly increased (P<0.05). [Conclusion] The effect of Isoquercitrin improving the db/db mice fatty acid metabolism may be by down-regulating the expression of SREBP1c , FAS mRNA, and up-regulating the expression of PGC1α, PPARαmRNA.关键词
异槲皮苷/脂肪酸代谢/基因表达Key words
Isoquercitrin/fatty acid metabolism/gene expression分类
医药卫生引用本文复制引用
许光远,李响,刘铜华,孙文,宋紫临,郭璇,吴丽丽,秦灵灵,侯丹,张茁,田硕..异槲皮苷对db/db小鼠肝脏脂肪酸代谢及相关基因表达的影响[J].天津中医药,2017,34(11):778-781,4.基金项目
北京市教育委员会高校重大成果转化项目. （）
