天然产物研究与开发2017，Vol.29Issue(10)：1683-1687,5.DOI:10.16333/j.1001-6880.2017.10.009
链霉菌Streptomyces sp.HS-NF-496中两个Anthrabenzoxocinone类化合物
Two Anthrabenzoxocinone Metabolites from Streptomyces sp.HS-NF-496
杜敏娜 1姜南 1张灵坚 1张杭锋 1齐欢 1张辉 1王继栋1
作者信息
- 1. 浙江海正药业股份有限公司,台州318000
- 折叠
摘要
Abstract
Two anthrabenzoxocinone metabolites,(-)-(6R,16R) 10-Cl-ABX (1) and (-)-(6R,16R)-ABX (2),were isolated from the fermentation broth of Streptomyces sp.HS-NF-496.Their structures were determined on the basis of spectroscopic analysis,including 1D and 2D NMR techniques,CD as well as ESI-MS and comparison with data from the literatures.Bioassay results showed that 1 and 2 exhibited weak cytotoxic activity against three tumor cell lines A549,HCT-116 and SF-268 and moderate antimicrobial activity against Pseudomonas aeruginosa,Staphylococcus aureus,Bacillus subtilis and Methicillin-resistant S.aureus.The absolute configuration of 1 was reported for the first time.关键词
链霉菌/anthrabenzoxocinones/细胞毒性/抗细菌活性Key words
Streptomyces sp./anthrabenzoxocinones/cytotoxicity/antibacterial activity分类
医药卫生引用本文复制引用
杜敏娜,姜南,张灵坚,张杭锋,齐欢,张辉,王继栋..链霉菌Streptomyces sp.HS-NF-496中两个Anthrabenzoxocinone类化合物[J].天然产物研究与开发,2017,29(10):1683-1687,5.
