外科理论与实践2017，Vol.22Issue(5)：401-406,6.DOI:10.16139/j.1007-9610.2017.05.009
乳腺癌保乳术后放疗两种调强技术的心肺剂量体积比较
Dosimetric comparison of cardiac and pulmonary dose-volume between two radiotherapy after breast conserving surgery in breast cancer
吴华玲 1许赪 1蔡钢 1曹璐 1陈佳艺1
作者信息
- 1. 上海交通大学医学院附属瑞金医院放射治疗科,上海200025
- 折叠
摘要
Abstract
Objective To explore the difference in dose distribution in normal tissue between forward-planned field in field intensity modulated radiation therapy (FP-FIF-IMRT)and inverse-planned intensity modulated radiation therapy (IP-IMRT)after breast conserving surgery in breast cancer.Methods The patients with breast cancer who received radiotherapy after breast conserving surgery from January 2016 to July 2016 were retrospectively studied.The prescribed dose was 50 Gy in 25 sessions to breast and 10 Gy in 5 sessions to tumor bed subsequently.The whole heart and ipsilateral lung were outlined on CT.Whose dose-volume histogram parameters of heart and lungs were quantified in the radiotherapy planning system (ADAC Pinnacle).Results A total of 33 cases with left breast cancer received FP-FIF-IMRT and 15 cases received IP-IMRT.Twenty-three case with right breast cancer received FP-FIF-IMRT and 17 cases received IP-IMRT.V2 and V5 of heart in left breast cancer patients with FP-FIF-IMRT were lower than with IP-IMRT (P＜0.05).However,V40 of heart receiving FP-FIF-IMRT was slightly higher than with IP-IMRT (4.31％±2.47％ vs.2.39％±1.75％,P=0.009 5).Mean dose,V2 and V5 and V10 of the heart in right breast cancer patients were also lower than those receiving IP-IMRT (P＜ 0.05).Mean dose,V5,V10 and V20 of ipsilateral lung in both left and right breast cancer patients receiving FP-FIF-IMRT were lower than those receiving IP-IMRT (P＜0.05).Conclusions FP-FIF-IMRT could reduce the volume of low dose irradiated area of normal tissue of breast cancer patients in radiotherapy after breast conserving surgery when compared with IP-IMRT.However,IP-IMRT was more effective in limiting the volume of high dose irradiated area of heart.关键词
乳腺癌/放射治疗/野中野正向调强放疗/逆向调强放疗/剂量分布Key words
Breast cancer/Radiotherapy/Forward-planned field in field intensity modulated radiation therapy/Inverse-planned intensity modulated radiation therapy/Dose distribution分类
医药卫生引用本文复制引用
吴华玲,许赪,蔡钢,曹璐,陈佳艺..乳腺癌保乳术后放疗两种调强技术的心肺剂量体积比较[J].外科理论与实践,2017,22(5):401-406,6.
