畜牧兽医学报2017，Vol.48Issue(10)：1785-1795,11.DOI:10.11843/j.issn.0366-6964.2017.10.001
piRNA的形成及其在雌性动物中生物学功能研究进展
Research Progress on piRNA Formation and Function in Female Animals
摘要
Abstract
Following the discovery of siRNA and miRNA,a new class of small noncoding RNA,called piRNA,was found.piRNA can interact with Piwi subfamily proteins and they involve in piRNA pathways,which can protect genetic information of animal germ cells from the harmful effects of molecular parasites such as transposon.In recent years,piRNA biogenesis-related proteins and their biological effects were studied.It was found that a variety of Piwi subfamily proteins could bind to piRNA to form Piwi-piRNA complex.These complexes were involved in germ cells formation and development,germline stem cells differentiation,sex determination and other biological functions through the way of epigenetic regulation.In the present paper,we reviewed the research progress on the biogenesis and characteristics of piRNA,the ways of Piwi-piRNA complexes playing the biological roles and biological functions of piRNA in female animals,which will provide a reference for further research on regulatory mechanism of piRNA in female animal reproduction.关键词
piRNA/Piwi蛋白/表观遗传调控/雌性动物Key words
piRNA/Piwi protein/epigenetic regulation/female animals分类
生物科学引用本文复制引用
李春艳,任春环,刘秋月,胡文萍,王翔宇,曹晓涵,张子军,狄冉,储明星..piRNA的形成及其在雌性动物中生物学功能研究进展[J].畜牧兽医学报,2017,48(10):1785-1795,11.基金项目
国家自然科学基金项目(31572371 （）
31472078 （）
31402041) （）
宁夏农林科学院科技创新先导资金项目(DWJLC-2016001) （DWJLC-2016001）
中国农业科学院科技创新工程(ASTIP-IAS13) （ASTIP-IAS13）
国家肉羊产业技术体系专项(CARS-39) （CARS-39）
中央级公益性科研院所基本科研业务费专项(2013ywf-zd-1 （）
2015ywf-zd-2 （）
2015ywf-zd-8) （）
内蒙古自治区科技重大专项 （）
内蒙古自治区战略性新兴产业发展专项资金计划 （）
