畜牧兽医学报2017，Vol.48Issue(10)：1796-1806,11.DOI:10.11843/j.issn.0366-6964.2017.10.002
CD4基因的DNA甲基化修饰在家畜抗病育种中的应用
DNA Methylation Modification of CD4 Gene and Its Application in Livestock Diseases-Resistant Breeding
摘要
Abstract
CD4 molecular is mainly expressed on mature CD4+T cells surface.It can direct T cells normal differentiation and maturation,recognize antigen,mediate immune response and involve in immune regulation.DNA methylation modification is critical to regulating differentiation of T cell subsets.Especially,the DNA methylation of CD4 gene can significantly affect the amount and function of CD4+T cells,influence the ability of immune response and disease resistance of livestock,then against or adapt environmental changes.Up to date,studies have reported that DNA methylation of porcine and bovine CD4 gene can regulate immune responses of the host cells,while that of sheep and horse are rarely reported.To understand the molecular basis of complex diseases and provide novel breeding strategies against livestock diseases via molecular marker assistant selection methods,the progress on regulation mechanism of DNA methylation of livestock CD4 gene,and its effects on immune responses during CD4+T cells differentiation,as well its possible application in disease resistance breeding of livestock were reviewed and discussed in this paper.关键词
家畜/CD4基因/DNA甲基化/抗病育种Key words
livestock/CD4 gene/DNA methylation/disease-resistant breeding分类
生物科学引用本文复制引用
王晓铄,俞英,赵会敏,唐天,李凯,钱旭,张雪,图雅,郑云胜,王怀栋..CD4基因的DNA甲基化修饰在家畜抗病育种中的应用[J].畜牧兽医学报,2017,48(10):1796-1806,11.基金项目
内蒙古自然科学基金(2016BS0305) （2016BS0305）
国家自然科学基金(31272420 （）
31572361) （）
北京市奶牛产业创新团队项目(BAIC06-2017) （BAIC06-2017）
