中国当代儿科杂志2017，Vol.19Issue(11)：1129-1133,5.DOI:10.7499/j.issn.1008-8830.2017.11.001
极低/超低出生体重儿迟发型败血症发生情况及其危险因素分析
Incidence of late-onset sepsis in very low birth weight and extremely low birth weight infants and risk factors for late-onset sepsis
摘要
Abstract
Objective To investigate the incidence of late-onset sepsis (LOS) in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants in the neonatal intensive care unit (NICU) and the risk factors for LOS. Methods A retrospective analysis was performed for the clinical data of all VLBW and ELBW infants who were hospitalized in the NICU between January 2011 and December 2013. According to the presence or absence of LOS, these infants were divided into LOS group and non-LOS group. The incidence and mortality rates of LOS, common pathogenic bacteria, and risk factors for LOS were analyzed. Results Of the 226 VLBW and ELBW infants, 117 (51.8%) developed LOS, among whom 45 had a confirmed diagnosis of LOS and 72 had a clinical diagnosis of LOS. The LOS group had a significantly higher mortality rate than the non-LOS group [13.7% (16/117) vs 4.6% (5/109);P<0.05]. Bacterial culture found 51 strains of pathogenic bacteria, among which 32 (63%) were Gram-negative bacteria, 16 (31%) were Gram-positive bacteria, and 3 (6%) were fungi. The multivariate logistic regression analysis showed that gestational age, small for gestational age (SGA), duration of parenteral nutrition, peripherally inserted central catheter (PICC) placement, and mechanical ventilation were independent risk factors for LOS in VLBW and ELBW infants (OR=0.84, 1.59, 1.34, 3.11, and 4.55 respectively; P<0.05). Conclusions LOS has high incidence and mortality rates in VLBW and ELBW infants. Common pathogenic bacteria of LOS are Gram-negative bacteria. Low gestational age, long duration of parenteral nutrition, SGA, PICC placement, and mechanical ventilation may increase the risk of LOS in VLBW and ELBW infants.关键词
迟发型败血症/危险因素/极低出生体重儿/超低出生体重儿Key words
Late-onset sepsis/Risk factor/Very low birth weight infant/Extremely low birth weight infant引用本文复制引用
赵小朋,周伟,李旭芳,宋燕燕,张庭艳,梁红..极低/超低出生体重儿迟发型败血症发生情况及其危险因素分析[J].中国当代儿科杂志,2017,19(11):1129-1133,5.基金项目
广东省医学科研项目(A2015494). （A2015494）
