中国当代儿科杂志2017，Vol.19Issue(11)：1213-1218,6.DOI:10.7499/j.issn.1008-8830.2017.11.017
儿童Ph-like急性淋巴细胞白血病的研究进展
Research progress in Ph-like childhood acute lymphoblastic leukemia
摘要
Abstract
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a subtype of B-lineage ALL (B-ALL) that displays a gene expression profile (GEP) similar to Philadelphia chromosome-positive ALL (Ph+ALL). It has a diverse range of genetic alterations that activate cytokine receptor genes and kinase signaling pathways, frequently accompanied by abnormal transcription factors related to lymphatic development. Children with Ph-like ALL account for 15% of children with high-risk B-ALL. It has adverse clinical features and a poor prognosis. Tyrosine kinase inhibitors combined with chemotherapy can significantly improve the prognosis of children with Ph+ ALL, suggesting that targeted therapy based on the molecular cytogenetic abnormalities of Ph-like ALL has good research prospects. This paper expounds the genetic alterations, pathogenesis, clinical features, diagnostic measures, and potential therapeutic approaches of Ph-like childhood ALL based on recent research progress in Ph-like ALL.关键词
Ph-like急性淋巴细胞白血病/基因/诊断/酪氨酸激酶抑制剂/儿童Key words
Ph-like acute lymphoblastic leukemia/Gene/Diagnosis/Tyrosine kinase inhibitor/Child引用本文复制引用
唐雪..儿童Ph-like急性淋巴细胞白血病的研究进展[J].中国当代儿科杂志,2017,19(11):1213-1218,6.基金项目
自然科学基金青年基金项目(81600122). （81600122）
