中国临床药学杂志2017，Vol.26Issue(5)：315-319,5.
某三甲妇儿医院门诊超说明书用药调查分析
Survey and analysis on off-label drug use in outpatients of a maternity and child health hospital
摘要
Abstract
AIM To investigate the off-label drug use status in outpatients of Xiamen Maternity and Child Health Hospital within consecutive 6 weeks in 2016,and provide the data for the analysis and policy making of offlabel drug use in Chinese women and children.METHODS The outpatient prescriptions of pediatrics,gynecology and obstetrics were collected by stratified random sampling and off-label prescribing was determined according to the drug instructions.The comprehensive analysis of off-label drug use was performed in the following aspects:the age distribution of pediatrics,the category of off-label drug use and category of drugs.RESULTS Totally 12 766 outpatient prescriptions including 23 567 medical advices and involving 423 drugs were collected.The incidence rate of off-label prescribing was 23.51％,18％ and 29.55％ respectively by prescriptions,medical advices and drugs.The top 3 highest incidence rates of off-label drug use were 45.99％,27.45％ and 18.01％ respectively in newborn,infancy and adolescence.Off-label prescribing in pediatric outpatients occurred mainly in patient population (46.74％) and dosage/frequency/duration (39.04％),while occurred mostly in indication (52.22％) and route of administration (28.44％) in gynecology and obstetrics.In addition,this study found that most off-label drugs used in children were respiratory system agents (45.96％),anti-infectives (11.80％),Chinese patent drugs (10.98％),and in gynecology and obstetrics were hormonal agents (42.83％),solutions affecting water and electrolyte balance (31.89％),antineoplastic agents (8.50％).CONCLUSION This study suggests that off-label drug use in outpatients remains common in our hospital.It is urgent for medical institutions to improve management regulating off-label drug use so as to prevent drug-related risks and ensure medication safety.关键词
超说明书用药/儿科/妇产科/门诊/用药风险Key words
off-label drug use/pediatrics/gynecology and obstetrics/outpatients/drug-related risk引用本文复制引用
陈瑶,杨剑辉,林武斌,吴雯,廖玉芳..某三甲妇儿医院门诊超说明书用药调查分析[J].中国临床药学杂志,2017,26(5):315-319,5.基金项目
厦门市科学技术局科技计划项目(编号3502Z20154032) （编号3502Z20154032）
