中国美容医学2017，Vol.26Issue(10)：68-70,3.
微小RNA21和TGF-β1在正常皮肤和增生性瘢痕组织中的表达研究
Expression of MicroRNA21 and TGF-β1 in Normal Skin and Hypertrophic Scar
地里夏提·库尔班1
作者信息
- 1. 新疆维吾尔自治区人民医院烧伤科 新疆 乌鲁木齐 830001
- 折叠
摘要
Abstract
Objective To investigate the expression of microRNA-21 (miRNA-21) gene and transforming growth factor-β(TGF-β1) gene in normal skin and hypertrophic scar tissue, and to analyze its correlation. Methods Collected from 16 hypertrophic scar tissues and adjacent normal skin tissues formed by burn and plastic surgery department in our hospital, total RNA was extracted from normal tissues and Hypertrophic scar tissue. The expressions of miRNA-21 and TGF-β1 gene in hypertrophic scar tissue and normal tissue were detected by RT-qPCR. The detection results were analyzed and compared, and the correlation analysis was carried out. Results The expression of miRNA-21 gene in hypertrophic scar tissue was significantly up-regulated, the difference was statistically significant(P<0.05), its expression level was 2.18 times of normal skin tissue. The expression of TGF-β1 in hypertrophic scar was higher than that in normal skin tissue(P<0.05). The expression level of TGF-β1 was 2.31 times higher than that of normal skin tissue. There was a positive correlation between the expression of miRNA-21 gene and the expression of TGF-β1 gene in hypertrophic scar tissue(r=0.836, P<0.01). Conclusion The abnormal expression of miRNA-21 and TGF-β1 gene in hypertrophic scar tissue may be related to the formation of scar tissue.关键词
增生性瘢痕/微小RNA21/TGF-β1Key words
hypertrophic scar/microRNA-21/TGF-β1分类
医药卫生引用本文复制引用
地里夏提·库尔班..微小RNA21和TGF-β1在正常皮肤和增生性瘢痕组织中的表达研究[J].中国美容医学,2017,26(10):68-70,3.
