中国实用外科杂志2017，Vol.37Issue(10)：1135-1138,4.DOI:10.19538/j.cjps.issn1005-2208.2017.10.17
腹腔镜热灌注化疗联合腹腔及系统化疗转化治疗胃癌腹膜转移1例报告
Case analysis of conversion therapy by laparoscopic HIPEC combined with intraperitoneal and systemic chemotherapy for gastric cancer peritoneal metastasis
摘要
Abstract
Objective To investigate the efficacy of laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) combined intraperitoneal and systemic chemotherapy in gastric cancer patients with peritoneal metastasis.Methods A gastric cancer patient whose peritoneal cancer index was 39 during laparoscopic exploration was admitted at Peking University Cancer Hospital Gastrointestinal Center.The patient received laparoscopic HIPEC with docetaxel,followed by 6 courses of intraperitoneal and intravenous PTX,along with S-1 orally.Results CT scan showed distinct response during post-treatment evaluation.A second look by laparoscopy was suggested by MDT.No tumor cell was found in the lavage fluid through abdominocentesis and no metastasis can be seen by laparoscopic exploration.Then total gastrectomy plus D2 minus No.10 lymph node dissection was performed.The patient recovered smoothly after surgery.The pathology confirmed a ypT3N2M1,moderate to poor-differentiated adenocarcinoma,from gastric antrum to body.By September 2017,the patient was still in postoperative treatment.Conclusion Laparoscopic HIPEC combined with intraperitoneal and systemic chemotherapy showed effective interim results in gastric cancer peritoneal metastasis conversion therapy and is deserved for further researches.关键词
胃癌/腹膜转移/腹腔热灌注化疗/腹腔化疗/转化治疗/腹腔镜手术Key words
gastric cancer/peritoneal metastasis/hyperthermic intraperitoneal chemotherapy/intraperitoneal chemotherapy/conversion therapy/laparoscopic surgery分类
医药卫生引用本文复制引用
薛侃,李子禹,李双喜,贾永宁,陕飞,张连海,唐磊,李忠武,季加孚..腹腔镜热灌注化疗联合腹腔及系统化疗转化治疗胃癌腹膜转移1例报告[J].中国实用外科杂志,2017,37(10):1135-1138,4.基金项目
科技部支撑计划(No.2014BAI09B02) （No.2014BAI09B02）
国家自然科学基金(No.81374016) （No.81374016）
