中国实用外科杂志2017，Vol.37Issue(10)：1143-1148,6.DOI:10.19538/j.cjps.issn1005-2208.2017.10.19
姑息性手术与支架植入术治疗不可切除晚期胃癌疗效Meta分析
Comparison of the outcome of palliative therapy and endoscopic stenting in unresectable gastric cancer: A Meta-analysis
摘要
Abstract
Objective To evaluate the safety and feasibility of palliative gastrojejunostomy (GJJ) and endoscopic stenting (ES) for gastric outlet obstruction (GOO) caused by unresectable gastric cancer.Methods The literatures before August 2017 in Pubmed,Elsevier,SPRINGER,Cochrane Library,CNKI,CBM and Wanfang database were searched extensively to retrieve the comparative studies of palliative GJJ and ES in unresectable gastric cancer with a relevance of study goal.The inclusion and exclusion criteria were formulated.After a quality evaluation,the data were extracted.Meta-analysis was conducted by the Stata 12.0 software.Results A total of thirteen studies met the inclusion criteria for meta-analysis.Compared with ES,the GJJ group had a higher rate of clinical success (OR=2.271,95％CI 1.539-3.352,P＜0.001),lower re-obstruction rate (OR=0.351,95％CI 0.248-0.496,P＜0.001),longer patency duration (WMD=243.386,95％CI 152.309-388.925,P＜0.001).However,the ES group had a shorter procedure time (WMD=112.548,95％CI 90.272-140.320,P＜0.001),faster resumption of oral intake (WMD=6.121,95％CI 4.616-8.118),and shorter duration of hospital stay(WMD=14.208,95％CI 9.578-21.077,P＜0.001).Procedure-related mortality and complications were not significantly different between the ES group and GJJ group.Conclusion Both GJJ and ES are effective procedures for the treatment of GOO caused by gastric cancer.GJJ should be considered a treatment option for patients with a long life expectancy and good performance status.关键词
晚期胃癌/姑息性胃空肠吻合术/支架植入术/Meta分析Key words
advanced gastric cancer/palliative gastrojejunostomy/endoscopic stenting/Meta-analysis分类
医药卫生引用本文复制引用
张文杰,徐皓,徐泽宽..姑息性手术与支架植入术治疗不可切除晚期胃癌疗效Meta分析[J].中国实用外科杂志,2017,37(10):1143-1148,6.基金项目
江苏省重点研发计划(社会发展)项目(No.BE2016786) （社会发展）
江苏省医学重点学科项目(No.ZDXKA2016005) （No.ZDXKA2016005）
