中国现代手术学杂志2017，Vol.21Issue(4)：251-256,6.DOI:10.16260/j.cnki.1009-2188.2017.04.003
食管癌组织中MTA1、SOX2的表达及与预后的关系研究
The Expression of MTA1 and SOX2 in Esophageal Cancer Tissues and the Relationship between MTA1, SOX2 and Prognosis
陈伟妍 1李桂艳 1辛春 1付勇强 1付春子1
作者信息
- 1. 辽宁中医药大学附属医院病理科, 沈阳 110032
- 折叠
摘要
Abstract
Objective To study the expression of tumor metastasis related gene MTA 1 and stem cell transcription factor SOX2 in esophageal cancer tissue , the correlation of MTA1 and SOX2, as well as the rela-tionship between them and prognosis , and to provide a theoretical basis for clinical early diagnosis and progno -sis. Methods The expression of MTA1 and SOX2 were detected with immunocytochemistry , Real-time PCR, Western blot method in 144 samples of esophageal carcinoma tissues .Combined with follow-up data more than 10 years, the relationship between the expression of MTA1 and SOX2, the correlation with clinical patho-logic features as well as its relationship with prognosis were analyzed . Results The result showed that both MTA1 and SOX2 were expressed in the cell nucleus of esophageal cancer .The negative or weakly positive rate , moderate positive rate and strong positive rate was 58.34%, 27.08% and 14.58% respectively in MTA1 ex-pression, and was 65.28%, 22.92% and 11.81% respectively in SOX2 expression.The expression of both MTA1 and SOX2 were related to T staging and clinical stage in esophageal cancer tissues , and negative correlated with overall survival span in esophageal cancer cases . Conclusions Tumor metastasis related factors MTA1 and stem cell transcription factor SOX2 were expressed with different degrees in esophageal cancer tissues , and there was correlation between them.The high expression of MTA1 and SOX2 simultaneously in esophageal cancer tissues were associated with poor prognosis .关键词
食管肿瘤/MTA1/SOX2/预后/免疫组织化学Key words
esophageal neoplasms/MTA1/SOX2/prognosis/immunohistochemistry分类
医药卫生引用本文复制引用
陈伟妍,李桂艳,辛春,付勇强,付春子..食管癌组织中MTA1、SOX2的表达及与预后的关系研究[J].中国现代手术学杂志,2017,21(4):251-256,6.
