中国畜牧兽医2017，Vol.45Issue(10)：3090-3099,10.DOI:10.16431/j.cnki.1671-7236.2017.10.037
当归补血汤提取物亚慢性毒性试验研究
Study on Subacute Toxicity Test of the Extact of Dangguibuxue Tang
摘要
Abstract
To evaluate the safety of the Dangguibuxue Tang (DBT) for animals,SD rats were administrated DBT by gavage once daily at 0,15,30 and 60 g/(kg · BW) for 28 consecutive days as control,low,medium and high dosage groups,and followed by a 14-day recovery period.The results showed that compared with control group,the weight gain and food intake of male rats in the high dosage group were extremely significantly decreased (P＜0.01).WBC and Lym of male rats in the high dosage group were significantly increased (P＜0.05),whereas ALT,TC and GLU were extremely significantly decreased (P＜0.01),PLT was significantly decreased (P＜ 0.05).RBC,HGB and ALT of female rats in high dosage group were extremely significantly decreased (P＜0.01).ALT and ALP of rats in medium dosage group were significantly or extremely significantly decreased (P＜0.05;P＜0.01).While in medium dosage group RET of male rats was significantly increased (P＜0.05) and HGB of the female rats were significantly decreased (P ＜0.05) 14 days after withdrawal.However,these indexes had no significant difference to control group at the end of recovery period.In addition,no changes were observed in the main organs of rats at macroscopic and microscopic level.The result showed that subacute administration of DBT was not toxic in SD rats,suggesting a safety use for animals.关键词
当归补血汤/大鼠/亚慢性毒性Key words
Dangguibuxue Tang/rat/subacute toxicity分类
医药卫生引用本文复制引用
李旭廷,王斌,李思聪,杨锐,李金良,张敏..当归补血汤提取物亚慢性毒性试验研究[J].中国畜牧兽医,2017,45(10):3090-3099,10.基金项目
四川省科技支撑计划(2015NZ0018) （2015NZ0018）
四川省基本科研业务费项目(SASA2013B07) （SASA2013B07）
四川省财政运行专项(SASA2014CZYX010) （SASA2014CZYX010）
