摘要
Abstract
OBJECTIVE:To probe into the clinical efficacy of tiotropium bromide combined with salmeterol fluticasone in treatment of moderate or severe chronic obstructive pulmonary disease ( COPD ) .METHODS:128 patients with moderate or severe COPD admitted into the Central Hospital of Qianjiang from Feb .2015 to Nov.2016 were selected and divided into observation group and control group via random number table , with 64 cases in each . Both groups were given conventional therapy , on that basis , the control group was treated with salmeterol fluticasone , while the observation group was given tiotropium bromide based on the control group .Clinical efficacy , indices of pulmonary function and incidences of adverse drug reactions of two groups were observed .RESULTS:The total effective rate of observation group (95.31%, 61/64) was significantly higher than that of the control group (79.69%, 51/64), with statistically significantly differences ( P <0.05); after treatment, the FEV1 and FEV1/FVC of both groups were significantly higher than those of before treatment , and those of observation group were significantly higher than the control group , with statistically significantly differences ( P<0.05 );the incidences of adverse drug reactions of observation group and control group were respectively 6.25%(4/64) and 7.81% (5/64), the difference had no statistical significance ( P>0.05 ) .CONCLUSIONS:The efficacy of tiotropium bromide combined with salmeterol fluticasone in treatment of moderate or severe COPD is remarkable , which can significantly improve patients ' pulmonary function , with less adverse reactions .关键词
噻托溴铵/沙美特罗替卡松/中重度慢性阻塞性肺疾病/临床疗效Key words
Tiotropium bromide/Salmeterol-fluticasone/Moderate or severe COPD/Clinical efficacy分类
医药卫生
