摘要
Abstract
OBJECTIVE:To probe into the clinical efficacy of Shenfu injection combined with edaravone injection in treatment of acute cerebral infarction .METHODS:120 patients with acute cerebral infarction admitted into Hengyang Traditional Chinese Medicine Hospital from Jun .2014 to Jun.2016 were selected and divided into control group and observation group via random number table , with 60 cases in each group .The control group was treated with edaravone injection, while the observation group was given Shenfu injection combined with edaravone injection , both groups received a 14-day treatment.The activities of daily living(ADL), national institutes of health stroke scale(NIHSS) scores and levels of inflammatory factors between two groups before and after treatment were compared , the clinical efficacy and incidence of adverse drug reactions of two groups were observed .RESULTS:Before treatment , there was no statistical significance in levels of ADL scores, NIHSS scores, C-reactive protein(CRP), tumor necrosis factor α(TNF-α) and interleukin 6(IL-6) between two groups(P>0.05).After treatment, the ADL scores of both groups had been significantly increased , and that of the observation group was significantly higher than the control group;the NIHSS scores , CRP, TNF-αand IL-6 of both groups had been significantly decreased , and those of the observation group were significantly lower than the control group , with statistically significant differences (P<0.05).The total effective rate of observation group was 93.33%(56/60), which was significantly higher than that of the control group (80.00%, 48/60), with statistically significant difference(P<0.05). The incidence of adverse drug reactions of observation group was 6.67%(4/60) , that of the control group was 3.33%(2/60), the difference had no statistical significance (P>0.05).CONCLUSIONS:The efficacy of Shenfu injection combined with edaravone injection in treatment of acute cerebral infarction is remarkable , with high safety.关键词
急性脑梗死/依达拉奉注射液/参附注射液/疗效/不良反应Key words
Acute cerebral infarction/Edaravone injection/Shenfu injection/Efficacy/Adverse drug reaction分类
医药卫生
