中国真菌学杂志2017，Vol.12Issue(5)：279-282,278,5.
8种抗真菌药物对浅表真菌病致病菌株体外敏感性检测
In vitro susceptibility testing of eight antifungal agents against pathogenic fungi isolated from superficial mycoses
吴伟伟 1王千 2龚杰 1万喆 1王爱平 1李若瑜1
作者信息
- 1. 北京大学第一医院皮肤性病科 北京大学真菌和真菌病研究中心,北京100034
- 2. 海南省皮肤病医院,海口570206
- 折叠
摘要
Abstract
Objective To investigate the in vitro activity of 8 antifungal agents against 100 strains of pathogenic fungi isolated from patitens with superficial mycoses.Methods The antifungal susceptibility testing was investigated following Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution methods.Eight antifungal agents were evaluated against 45 dermatophyte strains,35 Candida strains and 15 Malassezia strains.Results Our minimum inhibitory concentration (MIC) results revealed that terbinafine (GM MIC,0.011 μg/mL;MIC range,0.004-0.06 μg/mL) had the strongest antifungal activity against Dermatophyte,miconazole (GM MIC,0.147 μtg/mL;MIC range,0.015-1 μg/mL) against Candida,and ketoconazole (GM MIC,0.097 μg/mL;MIC range,0.03-1 μg/mL) against Malassezia.Conclusions The in vitro susceptibility testing indicates that common superficial pathogenic fungi exhibit variable susceptibilities to 8 antifungal agents.Ketoconazole has a potent antifungal activity for dermatophyte,Candida and Malassezia.Terbinafine and naftifine were the most active agents for Dermatophyte.关键词
抗真菌剂/药敏实验/微量液基稀释法/浅表真菌病Key words
antifungal agents/susceptibility testing/broth microdilution/superficial mycoses分类
医药卫生引用本文复制引用
吴伟伟,王千,龚杰,万喆,王爱平,李若瑜..8种抗真菌药物对浅表真菌病致病菌株体外敏感性检测[J].中国真菌学杂志,2017,12(5):279-282,278,5.
