中国肿瘤生物治疗杂志2017，Vol.24Issue(10)：1112-1117,6.DOI:10.3872/j.issn.1007-385x.2017.10.012
miR-141-3p在胃癌组织和患者血浆中的表达及其临床意义
Expression and clinical significance of miR-141-3p in cancer tissues and plasma of gastric cancer patients
摘要
Abstract
Objective:To investigate the relationship between miR-141-3p expression and prognosis and the clinical parameters of gastric cancer patients through detecting the expression of miR-141-3p in gastric cancer tissues and plasma.Methods:Tissue specimens and preoperative periphery venous blood specimens from 44 gastric cancer patients were collected during radical resection of gastric cancer at the Fourth Hospital of Hebei Medical University from May 2012 to January 2013;each tissue sample included cancer tissue (non-necrosis part) and the corresponding non-cancerous tissue,qRT-PCR was adopted to detect the expression of miR-141-3p in gastric cancer tissues,normal para-cancerous tissues and plasma of gastric cancer patients as well as healthy volunteers (25 cases).The relationship between miR-141-3p expression and DFS and clinical parameters were also investigated.Results:miR141-3p was dramatically decreased in gastric cancer tissues but significantly increased in plasma (all P＜0.01).In regard of tissue sample examination,DFS of high miR-141-3p expression group was significantly longer than that of low expression group (21.8 vs 10.3 months,P＜0.01),and miR-141-3p expression was positively correlated with DFS of patients (P＜0.01).In regard of plasma sample examination,DFS of high miR-141-3p expression group was significantly shorter than that of low expression group (9.1 vs 21.0 months,P＜0.01),and miR-141-3p expression was negatively correlated with DFS (P＜0.01).The plasma miR-141-3p expression was associated with TNM stage,lymph node metastasis and venous obstruction (P＜0.01).Conclusion:miR-141-3p was dramatically decreased in gastric cancer tissues and positively correlated with the prognosis;while its expression was significantly increased in plasma and negatively correlated with prognosis of patients,indicating that miR-141-3p could serve as a potential target for the timely treatment and the prognosis prediction of gastric cancer.关键词
胃癌/miR-141-3p/癌组织/血浆/预后Key words
gastric cancer/miR-141-3p/cancer tissue/plasma/prognosis分类
医药卫生引用本文复制引用
周欣亮,赵日旸,韩晶,范志松,李丹,赵连梅,桑梅香,单保恩..miR-141-3p在胃癌组织和患者血浆中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(10):1112-1117,6.基金项目
河北省卫计委医学科学研究基金资助项目(No.20170150) （No.20170150）
河北省科技计划资助项目(No.162777138).Project supported by the Medical Science Research Foundation of Health and Family Planing Commission of Hebei (No.20170150),and the Hebei Science and Technology Project(No.162777138) （No.162777138）
