中国肿瘤生物治疗杂志2017，Vol.24Issue(10)：1124-1128,5.DOI:10.3872/j.issn.1007-385x.2017.10.014
上皮性卵巢癌患者术前外周血中性粒细胞/淋巴细胞比值在诊断及复发预测中的作用
Role of peripheral neutrophil/lymphocyte ratio in the diagnosis and recurrence prediction of epithelial ovarian cancer
摘要
Abstract
Objective:To examine the application value of preoperative blood neutrophil to lymphocyte ratio (NLR) in the diagnosis and recurrence prediction of epithelial ovarian cancer (EOC).Methods:The complete clini cal and pathological information of 147 patients with benign ovarian tumor and 134 patients with EOC that treated in Affiliated Hospital of Qingdao University between January 2003 and January 2011 were retrospectively studied.The optimum cut-off value of the preoperative NLR to diagnose EOC was identified through receiver operator char acteristic (ROC) curve,and the patients were then classified into two groups according to this cut-off value.Univariate and multivariate analyses were performed to assess the high risk factors for the relapse of EOC within 5 years.Results:The optimal cut-off value of NLR was 2.04 to diagnose EOC.There were statistically significant differences in age,CA125 levels,FIGO staging,lymphatic metastasis and ascites formation between the NLR＜2.04 group and the NLR≥2.04 group (P＜0.05),but no significant discrimination was observed in pathological type and differentiation level (P＞0.05).Univariate and multivariate analyses revealed that NLR ≥2.04 was a risk factor the relapse of EOC within 5 years (P＜0.05).Conclusion:An elevated preoperative NLR value was correlated with EOC and multiple clinical indicators,which is an important independent relapse predictor for patients with EOC.关键词
上皮性卵巢癌/中性粒细胞/淋巴细胞比值/诊断/复发Key words
epithelial ovarian cancer(EOC)/neutrophil to lymphocyte ratio/diagnose/relapse分类
医药卫生引用本文复制引用
丁朝霞,闫丽萍,孙华芹,魏颖,李宁凤,陈爱平..上皮性卵巢癌患者术前外周血中性粒细胞/淋巴细胞比值在诊断及复发预测中的作用[J].中国肿瘤生物治疗杂志,2017,24(10):1124-1128,5.基金项目
青岛市市南区科技发展资助项目(No.2014-14-031-YY).Project supported by the Scientific and Technological Development of Qingdao South District(No.2014-14-031-YY) （No.2014-14-031-YY）
