中华耳科学杂志2017，Vol.15Issue(3)：345-349,5.DOI:10.3969/j.issn.1672-2922.2017.03.014
Rabconnectin-3α蛋白在听神经及毛细胞的病理生理学方面的生物学功能
Biological Functions of Rabconnectin-3αin Pathophysiology Involving Hair Cells and Auditory Nerve
摘要
Abstract
Rabconnectin-3(rbc3) protein is a member of the rab small GTP-binding protein family, and contains two subunits calledαandβ. Human rbc3αis encoded by the dmxl-2 (dmx like-2) gene which is located on chromosome 15 q2.1, consists of 3,036 amino acids, shows a calculated Mr of 339,753 and contains 12 WD domains. Research has found that rbc3αexpresses in both the brain and inner ear of rodent and primate animals, as well as in the lateral line or-gan of zebra fish. As relevant research continues, rbc3αis found not only to be involved in hearing loss, but also related with various diseases. For example, dmxl-2 mutation can affect the outcomes of hormonal therapy resistant breast can-cer. Besides, such mutations are related with aromatase excess syndrome. Therefore, the biological function of rabcon-nectin-3αhas become a hot topic of recent research. The present review summarizes research progress on the biological functions of rbc3αin relation to pathophysiology involving hair cells and auditory nerve in recent years.关键词
rabconnectin3α/dmxl-2/突触囊泡/听力下降/生物学功能Key words
Rabconnectin3α/Dmxl-2/Synapse Vesicle/Hearing Loss/Biological Function分类
医药卫生引用本文复制引用
卢嘉文,梅玲,汪雪玲,蔺欣,吴皓..Rabconnectin-3α蛋白在听神经及毛细胞的病理生理学方面的生物学功能[J].中华耳科学杂志,2017,15(3):345-349,5.基金项目
This work was supported by grants from the National Natural Science Foundation of China (No. 81570906),Shanghai science and technology commission foundation major projects (14DJ1400200). Shanghai science and technology commission foundation (14DZ2260300). 国家自然科学基金(81570906) （No. 81570906）
上海市科委基础重大项目(14DJ1400200) （14DJ1400200）
本项研究工作得到了上海市科学技术委员会的课题支持,编号为14DZ2260300 （）
