中华耳科学杂志2017，Vol.15Issue(3)：350-356,7.DOI:10.3969/j.issn.1672-2922.2017.03.015
骨髓间充质干细胞治疗感音神经性耳聋相关实验技术体系建设概要
Bone Marrow Mesenchymal Stem Cells in The Treatment of Sensorineural Hearing Loss:A Summary of The Related Technical Systems
摘要
Abstract
Sensorineural hearing loss (SNHL) can be caused by lesions of inner ear sensory cells. Treatment of SNHL remains a challenge for clinicians. A new treatment for SNHL is the repair and regeneration of inner ear sensory cells using stem cells. Numerous advances currently have been achieved in this area. Because of their low immunogenic-ity and easy accessibility, mesenchymal stromal cells (MSCs) have recently been considered as one of potentially ideal alternatives to restore degenerated inner ear sensory cells. However, research methods vary among research groups, from preparation to transplantation of stem cells, and no standardized process is established yet. This article focuses on the progress by Ding-hua Xie's group in treating SNHL and describes the latest advances worldwide. The paper aims to establish preliminary standards for stem cells preparation and quality control for treatment of SNHL, and to provide the-oretical evidence for clinical treatment of SNHL using stem cells.关键词
骨髓间充质干细胞/耳聋/实验技术体系Key words
Bone Marrow Mesenchymal Stem Cells/Sensorineural Hearing Loss/Technical System分类
医药卫生引用本文复制引用
彭韬,高水超,周媛,卿洁,徐娟,朱纲华,杨仕明,谢鼎华..骨髓间充质干细胞治疗感音神经性耳聋相关实验技术体系建设概要[J].中华耳科学杂志,2017,15(3):350-356,7.基金项目
This work was supported by grants from National Basic Research Program of China (973, grant number: 2012CB967904, 2012CB967900) and Independent innovation project of Central south university (grant number:2016zzts139) 国家重点基础研究发展计划(973):2012CB967900和2012CB967904 （973, grant number: 2012CB967904, 2012CB967900）
中南大学博士生自主创新项目:2016zzts139 （）
