肿瘤防治研究2017，Vol.44Issue(10)：682-685,4.DOI:10.3971/j.issn.1000-8578.2017.17.0164
100例甲状旁腺腺瘤的临床表现和首诊因素分析
Clinical Features and Factors for First Diagnosis of 100 Parathyroid Adenoma Patients
姚晓爱 1姜涛 1魏伯俊 2昌红 3宋秀霞 1文祯 1修磊 1张冬雪1
作者信息
- 1. 100038北京,首都医科大学附属北京世纪坛医院内分泌科
- 2. 100038北京,首都医科大学附属北京世纪坛医院耳鼻喉头颈外科
- 3. 100038北京,首都医科大学附属北京世纪坛医院病理科
- 折叠
摘要
Abstract
Objective To analyze the factors for the first diagnosis,clinical features,treatment and prognosis of parathyroid adenoma(PA) patients.Methods We reviewed the clinical date of 100 PA patients.Results The median preoperative parathyroid hormone(PTH) levels were 201pg/ml and serum calcium were (2.84±0.34)mmol/L in 100 PA patients.The first diagnoses due to the skeletal system and urinary system symptoms were observed in 17％ and 12％ of patients(P=0.000);those due to hypercalcemia and parathyroid placeholder found in physical examination were 32％ and 16％ of patients(P=0.000).The 100 cases were composed of 62％ bone types,43％ kidney type,33％ skeletal and renal involvements(P=0.000).The localization positive rate of 99Tcm-MIBI scan,ultrasonography,MRI and CT were 93.61％,82.52％,77.78％ and 74％(P=0.057).Nineteen cases with bilateral neck explorations,23 cases with unilateral neck exploration and 58 cases with no exploration were performed.Intraoperative parathyroid hormone monitoring during parathyroidectomy for PA was used commonly.PTH,serum calcium on postoperative day 1 significantly decreased and blood phosphorus increased obviously(P=0.000),while five cases developed chronic hypoparathyroidism.Conclusion Blood calcium screening should be routinely used.PTH screening for patients with bone pain,fracture,urinary calculi and parathyroid placeholder is recommended.99Tcm-MIBI scan is preferred for the localization.Intraoperative parathyroid hormone monitoring during parathyroidectomy can improve the success rate of operation.关键词
原发性甲状旁腺功能亢进症/甲状旁腺腺瘤/临床表现/诊断因素Key words
Primary hyperparathyroidism/Parathyroid adenoma/Clinical features/Diagnosis factor分类
医药卫生引用本文复制引用
姚晓爱,姜涛,魏伯俊,昌红,宋秀霞,文祯,修磊,张冬雪..100例甲状旁腺腺瘤的临床表现和首诊因素分析[J].肿瘤防治研究,2017,44(10):682-685,4.
