肿瘤防治研究2017，Vol.44Issue(10)：689-693,5.DOI:10.3971/j.issn.1000-8578.2017.17.0031
时间调节诱导化疗序贯洛铂同期放化疗治疗局部晚期头颈部鳞癌临床分析
Clinical Observation of Induction Chrono-chemotherapy Followed by Concurrent Lobaplatin Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma
陈宇 1唐红 1吴伟莉 1金风 1李媛媛 1龙金华 1龚修云 1陈潇潇 1黄诗颖 1周亚1
作者信息
- 1. 550001贵阳,贵州医科大学附属医院,贵州省肿瘤医院头颈肿瘤科
- 折叠
摘要
Abstract
Objective To observe the efficacy and side effects of induction chrono-chemotherapy combined with concurrent Lobaplatin chemoradiotherapy on locally advanced head and neck squamous cell carcinoma patients.Methods Thirty patients with locally advanced head and neck squamous cell carcinoma were treated with TPF regimen induction chrono-chemotherapy followed by concurrent lobaplatin chemoradiotherapy.Results The median follow-up was performed for 23 months.The effective rate after chemotherapy was 77％.That after simultaneous radiotherapy and chemotherapy was 93％.The overall survival rate,progression-free survival rate,local recurrence-free survival rate and distant metastasis-free survival rates of one year were 83.3％,83.3％,89.4％ and 96.3％;those of two years were 71.6％,68.4％,73.4％ and 86％,those of three years were 65.1％,62.2％,66.8％ and 78.2％,respectively.The main toxicities of introduction chemotherapy were 3-4 grade of platelet reduction in one case,3-4 grade of white blood cells reduction in seven cases,and 3-4 grade of neutropenia reduction in nine cases.The main toxicities of concurrent chemoradiotherapy were 3-4 grade of oral mucositis in four cases,3-4 levels of thrombocytopenia in seventeen cases,3-4 grades of leukopenia in twelve cases and 3-4 grade of neutropenia reduction in ten cases.Conclusion The clinical efficacy of TPF regimen induction chrono-chemotherapy combined with concurrent Lobaplatin chemoradiotherapy is good,with tolerated side effects,but still need to expand the number of cases for long-term follow-up study.关键词
头颈部鳞癌/时间调节化疗/洛铂/同期放化疗Key words
Head and neck squamous cell carcinoma/Induction chrono-chemotherapy/Lobaplatin/Concurrent chemoradiotherapy分类
医药卫生引用本文复制引用
陈宇,唐红,吴伟莉,金风,李媛媛,龙金华,龚修云,陈潇潇,黄诗颖,周亚..时间调节诱导化疗序贯洛铂同期放化疗治疗局部晚期头颈部鳞癌临床分析[J].肿瘤防治研究,2017,44(10):689-693,5.
