肿瘤防治研究2017，Vol.44Issue(10)：701-705,5.DOI:10.3971/j.issn.1000-8578.2017.17.0233
T淋巴细胞免疫球蛋白黏蛋白-3在肿瘤免疫中的研究进展
Advances of T cell Immunoglobulin Mucin-3 in Tumor Immunity
浦飞飞 1邵增务2
作者信息
- 1. 430022武汉,华中科技大学同济医学院附属协和医院骨科
- 2. 430022武汉,武汉市第一医院,武汉市中西医结合医院骨科
- 折叠
摘要
Abstract
Malignant tumor incidence increases year by year,harming human health seriously.Current treatments include radiotherapy,chemotherapy and molecular targeted therapy.T cell-mediated immune cells play a key role in the body's anti-tumor effect.In the process of immune response,the participation of coordinated stimulus signals is required to activate T cells,and these signals need "immune checkpoints" to be regulated.TIM-3,as a negative regulatory molecule,expresses selectively on activated Thl cell surface and plays an important regulatory role in the development of a variety of tumors.Therefore,we review the research advances of TIM-3 in tumor immunology through TIM-3 structure,ligands,expression in tumor,mechanism of immune regulation and immunotherapy.关键词
T淋巴细胞免疫球蛋白黏蛋白-3(TIM-3)/肿瘤/免疫Key words
T cell immunoglobulin mucin-3(TIM-3)/Cancer/Immunology分类
医药卫生引用本文复制引用
浦飞飞,邵增务..T淋巴细胞免疫球蛋白黏蛋白-3在肿瘤免疫中的研究进展[J].肿瘤防治研究,2017,44(10):701-705,5.
