安徽中医药大学学报2017，Vol.36Issue(5)：13-17,5.DOI:10.3969/j.issn.2095-7246.2017.05.005
1468例类风湿关节炎患者终点事件发生情况队列研究
Outcome Events of 1468 Patients with Rheumatoid Arthritis: A Cohort Study
摘要
Abstract
Objective To investigate the incidence of outcome events of patients with rheumatoid arthritis (RA) in The First Affiliated Hospital of Anhui University of Chinese Medicine using a cohort study,as well as related factors for the development of outcome events.Methods The patients who were diagnosed with RA in The First Affiliated Hospital of Anhui University of Chinese Medicine from January 2012 to June 2016 were enrolled,and their general data were collected.Telephone follow-up was performed to record the use of traditional Chinese medicine (TCM) (according to the medication time,the patients were divided into non-exposure group and low-,medium-,and high-exposure groups) and the incidence of outcome events.The laboratory markers during first admission were collected for RA patients who were followed up successfully,and a logistic regression analysis was performed to investigate the association between factors and the incidence of outcome events in RA patients.Results A total of 1 812 RA patients were enrolled,among whom 1 468 patients were followed up successfully,and 80 patients experienced outcome events.TCM exposure was an influencing factor for all-cause death,and age and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) increased the mortality rate.TCM exposure was also an influencing factor for recurrence and readmission,and erythrocyte sedimentation rate,superoxide dismutase,and platelet count increased the incidence rate of recurrence and readmission.TCM exposure and anti-rheumatic drugs were influencing factors for extra-articular lesions,and age and anti-CCP Ab increased the risk of extra-articular lesions.TCM exposure was an influencing factor for surgical treatment.Conclusion TCM intervention is an influencing factor for outcome events in RA patients,and the incidence of outcome events decreases with the increasing intensity of TCM exposure.关键词
类风湿关节炎/终点事件/队列研究/中医药治疗Key words
Rheumatoid arthritis/Outcome event/Cohort study/Traditional Chinese medicine treatment分类
医药卫生引用本文复制引用
文建庭,刘健,万磊,忻凌,董文哲,方妍妍..1468例类风湿关节炎患者终点事件发生情况队列研究[J].安徽中医药大学学报,2017,36(5):13-17,5.基金项目
中医药行业科研专项(201307001) （201307001）
中央引导地方科技发展专项(财教[2016]1188) （财教[2016]1188）
安徽省科技攻关项目(1604a0802085) （1604a0802085）
