儿科药学杂志2017，Vol.23Issue(11)：8-10,3.DOI:10.13407/j.cnki.jpp.1672-108X.2017.11.003
新生儿ABO溶血症与O型血母亲抗体效价相关性研究
Correlation between the Newborn with ABO Hemolytic Disease and Antibody Titer of the Mother with Type O Blood
摘要
Abstract
Objective:To investigate the correlation between the newborn with ABO hemolytic disease (ABO-HDN) and the antibody titer of the mother with type O blood.Methods:Seven hundreds and twelve cases of type O blood mothers of newborns were selected as a research object,the ABO-HDN of newborns with type A blood and type B blood were tested,and the mother's blood were taken for anti-A/B immunoglobulin G (IgG) titer detection,relationship between maternal anti IgG titer and the incidence of ABO-HDN were analyzed.Results:A total of 111 neonates with ABO-HDN positive were detected in this group,and the incidence of ABO-HDN was 15.59％ (111/712).The incidence of ABO-HDN was positively correlated with the titer of maternal antibody IgG (r =0.96,P＜0.01).There was no significant correlation between the time of jaundice and the anti IgG titer of ABO-HDN in children (P＞0.05).The indications of phototherapy,the incidence of anemia in neonates within 1 week and exchange transfusion rate of mother anti-titers ≤ 1 ∶ 64 group were all lower than those in the other two groups (P＜0.05).The incidence of anemia in neonates within 1 week and exchange transfusion rate of mother anti-titers ≥1 ∶ 256 group were significantly higher than those in the mother anti-titers =1:128 group (P＜ 0.05).Conclusion:For the blood type A or B blood newborns of type O blood mothers,the early detection of three items of hemolysis and antibody titer can predict the possibility and severity of hemolytic disease in newborns.关键词
ABO溶血症/O型血/抗体效价Key words
ABO hemolytic disease/type O blood/antibody titer分类
医药卫生引用本文复制引用
李雪瑞,付琳,马正民,宋少峰..新生儿ABO溶血症与O型血母亲抗体效价相关性研究[J].儿科药学杂志,2017,23(11):8-10,3.
