儿科药学杂志2017，Vol.23Issue(11)：14-17,4.DOI:10.13407/j.cnki.jpp.1672-108X.2017.11.005
枸橼酸咖啡因联合双水平正压通气治疗早产儿呼吸暂停疗效观察
Curative Effect Observation of Caffeine Citrate Combined with Duo Positive Airway Pressure in the Treatment of Apnea of Prematurity
摘要
Abstract
Objective:To evaluate the effects of caffeine citrate combined with duo positive airway pressure in treatment of apnea of prematurity (AOP).Methods:Fifty-eight AOP children treated in neonatal intensive care unit (NICU) of Xuzhou Central Hospital from July 2014 to June 2015 were randomly divided into 3 groups:study group (20 cases),control group 1 (19 cases),control group 2 (19 cases).All children were received routine care and basal treatment.The children in study group were treated with caffeine citrate combined with duo positive airway pressure (DuoPAP).The children in control group 1 were treated with caffeine citrate.The children in control group 2 (19 cases) were treated with DuoPAP.If the treatment was failed,trachea cannula and mechanical ventilation were used immediately as salvage therapy.The methods of analysis of variance and chi-square test were used to analyze the total oxygen inhaling time,hospitalization time,endotracheal intubation assisted ventilation rate and occurring rate of prematurity complication.Results:The total effective rate in study group (90.0％) was higher than that in the control group 1 (52.6％) and the control group 2 (42.1％) (P＜0.05).There was no significant difference between control group 1 and control group 2 (P＞0.05).The total oxygen inhaling time and hospitalization time in study group were significantly shorter than the two control groups (P＜0.05).The endotracheal intubation assisted ventilation rate in study group (10.0％) was lower than the control group (31.6％),there were no significant differences between three groups (P ＞ 0.05).There were no significant differences between the three groups in occurring rate of prematurity complication (P＞0.05).Conclusion:Caffeine citrate combined with DuoPAP therapy has significant clinical effect in the treatment of AOP,it is worthy of clinical promotion.关键词
枸橼酸咖啡因/双水平正压通气/早产儿/呼吸暂停Key words
caffeine citrate/duo positive airway pressure/premature/apnea分类
医药卫生引用本文复制引用
刘枭,周彬,吴杰斌,金宝,王彦波,王云..枸橼酸咖啡因联合双水平正压通气治疗早产儿呼吸暂停疗效观察[J].儿科药学杂志,2017,23(11):14-17,4.基金项目
徐州市社会发展项目,编号KC14SH025. （）
