法医学杂志2017，Vol.33Issue(4)：388-392,5.DOI:10.3969/j.issn.1004-5619.2017.04.012
贵州汉族19个STR基因座多态性及法医学应用
Polymorphisms of 19 STR Loci in Guizhou Han Population and Their Forensic Application
摘要
Abstract
Objective To investigate the allelic distribution of 19 autosomal STR loci in Guizhou Han population,and to estimate the forensic application value.Methods The 19 autosomal STR loci in 520 unrelated healthy individuals from Guizhou Han population were studied using GoldeneyeTM 20A kit.The 310 genetic analyzer was used for capillary electrophoresis,and the GeneMapper(R) ID v3.1 for genotyping.Results The heterozygosis,the discrimination power,the probability of exclusion,the polymorphism information content,the cumulative discrimination power and the cumulative probability of exclusion of the 19 STR loci were 0.603 8-0.9164,0.7900-0.985 6,0.295 5-0.8269,0.553 5-0.9089,1-1.2300×10-22 and 0.999 999 99,respectively.Compared with other five Han populations in pairwise allelic frequencies,Guizhou Han only had significant differences with Shandong Han,Liaoning Han and Shanxi Han.Conclusion The 19 autosomal STR loci such as D19S433 have a highly genetic polymorphic in Guizhou Han population,which have application values in the researches of population genetics and forensic genetics.关键词
法医遗传学/多态现象,遗传/短串联重复序列/GoldeneyeTM DNA身份鉴定系统20A试剂盒/汉族/贵州Key words
forensic genetics/polymorphism, genetics/short tandem repeat/GoldeneyeTM DNA ID 20A Kit/Han population/Guizhou分类
社会科学引用本文复制引用
赵勤松,任峥,张红玲,戴佳琳,王杰,喻芳,黄江..贵州汉族19个STR基因座多态性及法医学应用[J].法医学杂志,2017,33(4):388-392,5.基金项目
贵州省高校工程技术研究中心资助项目(黔科合KY字[2013]114号) （黔科合KY字[2013]114号）
贵州省现代法医司法鉴定工程研究中心资助项目(黔发改高技[2016]1345号) （黔发改高技[2016]1345号）
